E Numbers - Eliminating Additives from Your ADHD Child's Diet

It's called an elimination diet and some people believe that eliminating additives from your ADHD child's diet may improve ADHD symptoms.

Some people believe that eliminating additives from your ADHD child's diet may improve ADHD symptoms. Information on additives that should be avoided.People often ask us about information for E Numbers. Below is an extract from a very good source detailing which additives correspond to each of the E numbers.

This may help you decide if there is something you feel that you would like to try to eliminate from your ADHD child's diet. One thing, however, we need to make very clear is that to remove anything from a child's diet can be dangerous or have adverse effects. So we would always encourage that you seek expert advice from a professional before embarking on any form of elimination diet.

This is extracted from the book "E For Additives" about elimination diets

"First, this means cutting out all food and drink containing synthetic colours or flavours, avoiding glutamates, nitrites, nitrates, BHA, BHT and benzoic acid. Second, for the first four to six weeks, foods containing natural salicylates (like aspirin chemically) should be avoided and then re-introduced one at a time to see if they cause problems. Such foods include almonds, apples, apricots, peaches, plums, prunes, oranges, tomatoes, tangerines, cucumbers, most soft fruits, cherries, grapes and raisins.

The additives that are recommended should be avoided are:

  • E102 Tartrazine
  • E104 Quinoline Yellow
  • E107 Yellow 2G
  • E110 Sunset Yellow FCF
  • E120 Cochineal
  • E122 Carmoisine
  • E125 Amaranth
  • E124 Ponceau 4R
  • E127 Erythrosine
  • E128 Red 2G
  • E132 Indigo Carmine
  • E135 Brilliant blue FCF
  • E150 Caramel
  • E151 Black PN
  • E154 Brown FK
  • E155 Brown HT
  • El60(b) Annatto
  • E210 Benzoic Acid
  • E211 Sodium benzoate
  • E220 Sulphur dioxide
  • E250 Sodium nitrate
  • E251 Sodium nitrate
  • E320 Butylated hydroxyanisole
  • E321 Butylated hydroxytoluene

Plus another antioxidant preservative not used in the UK TBHQ (Monotertiary butylhydroxylquinone)

Additives which are either dangerous to asthmatics or aspirin-sensitive people, and could reasonably be added to the listing, or should not be used in food intended for babies or young children are:

  • E212 Potassium benzoate
  • E213 Calcium benzoate
  • E214 Ethyl 4-hydroxybenzoate
  • E215 Ethyl 4-hydroxybenzoate, sodium salt
  • E216 Propyi 4-hydroxybenzoate
  • E217 Propyi 4-hydroxybenzoate, sodium salt
  • E218 Methyl 4-hydroxybenzoate
  • E219 Methyl 4-hydroxybenzoate, sodium salt
  • E310 Propyl gallate
  • E311 Octyl gallate
  • E312 Dodecyl gallate
  • E621 Sodium hydron L-glutamate (monoSodium glutamate)
  • E622 Potassium hydrogen L-glutamate (monoPotassium glutamate)
  • E623 Calcium dihydrogen di-L-glutamate (calcium glutamate)
  • E627 Guanosine 5'-(diSodium phosphate)
  • E631 Inosine 5'-(diSodium phosphate)
  • E635 Sodium 5'-ribonucleotide

Source: "E for Additives" by Maurice Hanssen with Jill Marsden"


 


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APA Reference
Staff, H. (2008, December 3). E Numbers - Eliminating Additives from Your ADHD Child's Diet, HealthyPlace. Retrieved on 2024, October 5 from https://www.healthyplace.com/adhd/articles/eliminating-additives-from-your-adhd-childs-diet

Last Updated: February 12, 2016

Aricept: Cholinesterase Inhibitor

Detailed information on Aricept, a medication used in the treatment of Alzheimer's Disease. Usage, dosage, side-effects and more.

Aricept is a anticholinesterase medication used in the treatment of Alzheimer's Disease. Detailed info on usage, dosage, side-effects of Aricept.

Brand Name: Aricept®
Generic Name: Donepezil Hydrochloride

Aricept (Donepezil Hydrochloride) is an Anticholinesterase medication used in treatment of Alzheimer's Disease. Detailed info on uses, dosage and side-effects of Aricept below.

Contents:

Description
Pharmacology
Indications and Usage
Contraindications
Warnings
Precautions
Drug Interactions
Adverse Reactions
Overdose
Dosage
Supplied

Aricept patient information (in plain English)

Description

ARICEPT® (donepezil hydrochloride) is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as ( ±)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride. Donepezil hydrochloride is commonly referred to in the pharmacological literature as E2020. It has an empirical formula of C24H29NO3HCl and a molecular weight of 415.96. Donepezil hydrochloride is a white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile and practically insoluble in ethyl acetate and in n-hexane.

Aricept Structure

ARICEPT® is available for oral administration in film-coated tablets containing 5 or 10 mg of donepezil hydrochloride. Inactive ingredients are lactose monohydrate, corn starch, microcrystalline cellulose, hydroxypropyl cellulose, and magnesium stearate. The film coating contains talc, polyethylene glycol, hypromellose and titanium dioxide. Additionally, the 10 mg tablet contains yellow iron oxide (synthetic) as a coloring agent.

ARICEPT® ODT tablets are available for oral administration. Each ARICEPT® ODT tablet contains 5 or 10 mg of donepezil hydrochloride. Inactive ingredients are carrageenan, mannitel, colloidal silicon dioxide and polyvinyl alcohol. Additionally, the 10 mg tablet contains ferric oxide (yellow) as a coloring agent.

Clinical Pharmacology

Current theories on the pathogenesis of the cognitive signs and symptoms of Alzheimer's Disease attribute some of them to a deficiency of cholinergic neurotransmission.

Donepezil hydrochloride is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, donepezil's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that donepezil alters the course of the underlying dementing process.


 


Clinical Trial Data

The effectiveness of ARICEPT® as a treatment for Alzheimer's Disease is demonstrated by the results of two randomized, double-blind, placebo-controlled clinical investigations in patients with Alzheimer's Disease (diagnosed by NINCDS and DSM III-R criteria, Mini-Mental State Examination ≥ 10 and ≤ 26 and Clinical Dementia Rating of 1 or 2). The mean age of patients participating in ARICEPT® trials was 73 years with a range of 50 to 94. Approximately 62% of patients were women and 38% were men. The racial distribution was white 95%, black 3% and other races 2%.

Study Outcome Measures: In each study, the effectiveness of treatment with ARICEPT® was evaluated using a dual outcome assessment strategy.

The ability of ARICEPT® to improve cognitive performance was assessed with the cognitive subscale of the Alzheimer's Disease Assessment Scale (ADAS-cog), a multi-item instrument that has been extensively validated in longitudinal cohorts of Alzheimer's Disease patients. The ADAS-cog examines selected aspects of cognitive performance including elements of memory, orientation, attention, reasoning, language and praxis. The ADAS-cog scoring range is from 0 to 70, with higher scores indicating greater cognitive impairment. Elderly normal adults may score as low as 0 or 1, but it is not unusual for non-demented adults to score slightly higher.

The patients recruited as participants in each study had mean scores on the Alzheimer's Disease Assessment Scale (ADAS-cog) of approximately 26 units, with a range from 4 to 61. Experience gained in longitudinal studies of ambulatory patients with mild to moderate Alzheimer's Disease suggest that they gain 6 to 12 units a year on the ADAS-cog. However, lesser degrees of change are seen in patients with very mild or very advanced disease because the ADAS-cog is not uniformly sensitive to change over the course of the disease. The annualized rate of decline in the placebo patients participating in ARICEPT® trials was approximately 2 to 4 units per year.

The ability of ARICEPT® to produce an overall clinical effect was assessed using a Clinician's Interview Based Impression of Change that required the use of caregiver information, the CIBIC plus. The CIBIC plus is not a single instrument and is not a standardized instrument like the ADAS-cog. Clinical trials for investigational drugs have used a variety of CIBIC formats, each different in terms of depth and structure.

As such, results from a CIBIC plus reflect clinical experience from the trial or trials in which it was used and cannot be compared directly with the results of CIBIC plus evaluations from other clinical trials. The CIBIC plus used in ARICEPT® trials was a semi-structured instrument that was intended to examine four major areas of patient function: General, Cognitive, Behavioral and Activities of Daily Living. It represents the assessment of a skilled clinician based upon his/her observations at an interview with the patient, in combination with information supplied by a caregiver familiar with the behavior of the patient over the interval rated. The CIBIC plus is scored as a seven point categorical rating, ranging from a score of 1, indicating "markedly improved," to a score of 4, indicating "no change" to a score of 7, indicating "markedly worse." The CIBIC plus has not been systematically compared directly to assessments not using information from caregivers (CIBIC) or other global methods.

Thirty-Week Study

In a study of 30 weeks duration, 473 patients were randomized to receive single daily doses of placebo, 5 mg/day or 10 mg/day of ARICEPT®. The 30-week study was divided into a 24-week double-blind active treatment phase followed by a 6-week single-blind placebo washout period. The study was designed to compare 5 mg/day or 10 mg/day fixed doses of ARICEPT® to placebo. However, to reduce the likelihood of cholinergic effects, the 10 mg/day treatment was started following an initial 7-day treatment with 5 mg/day doses.

Effects on the ADAS-cog: Figure 1 illustrates the time course for the change from baseline in ADAS-cog scores for all three dose groups over the 30 weeks of the study. After 24 weeks of treatment, the mean differences in the ADAS-cog change scores for ARICEPT® treated patients compared to the patients on placebo were 2.8 and 3.1 units for the 5 mg/day and 10 mg/day treatments, respectively. These differences were statistically significant. While the treatment effect size may appear to be slightly greater for the 10 mg/day treatment, there was no statistically significant difference between the two active treatments.

Following 6 weeks of placebo washout, scores on the ADAS-cog for both the ARICEPT® treatment groups were indistinguishable from those patients who had received only placebo for 30 weeks. This suggests that the beneficial effects of ARICEPT® abate over 6 weeks following discontinuation of treatment and do not represent a change in the underlying disease. There was no evidence of a rebound effect 6 weeks after abrupt discontinuation of therapy.

Aricept Figure 1

Figure 2 illustrates the cumulative percentages of patients from each of the three treatment groups who had attained the measure of improvement in ADAS-cog score shown on the X axis. Three change scores, (7-point and 4-point reductions from baseline or no change in score) have been identified for illustrative purposes and the percent of patients in each group achieving that result is shown in the inset table.

The curves demonstrate that both patients assigned to placebo and ARICEPT® have a wide range of responses, but that the active treatment groups are more likely to show the greater improvements. A curve for an effective treatment would be shifted to the left of the curve for placebo, while an ineffective or deleterious treatment would be superimposed upon or shifted to the right of the curve for placebo, respectively.

Aricept Figure 2

Effects on the CIBIC plus: Figure 3 is a histogram of the frequency distribution of CIBIC plus scores attained by patients assigned to each of the three treatment groups who completed 24 weeks of treatment. The mean drug-placebo differences for these groups of patients were 0.35 units and 0.39 units for 5 mg/day and 10 mg/day of ARICEPT®, respectively. These differences were statistically significant. There was no statistically significant difference between the two active treatments.

hp-me-aricept3

Fifteen-Week Study

In a study of 15 weeks duration, patients were randomized to receive single daily doses of placebo or either 5 mg/day or 10 mg/day of ARICEPT® for 12 weeks, followed by a 3-week placebo washout period. As in the 30-week study, to avoid acute cholinergic effects, the 10 mg/day treatment followed an initial 7-day treatment with 5 mg/day doses.

Effects on the ADAS-Cog: Figure 4 illustrates the time course of the change from baseline in ADAS-cog scores for all three dose groups over the 15 weeks of the study. After 12 weeks of treatment, the differences in mean ADAS-cog change scores for the ARICEPT® treated patients compared to the patients on placebo were 2.7 and 3.0 units each, for the 5 and 10 mg/day ARICEPT® treatment groups respectively. These differences were statistically significant. The effect size for the 10 mg/day group may appear to be slightly larger than that for 5 mg/day. However, the differences between active treatments were not statistically significant.

Aricept Figure 4

Following 3 weeks of placebo washout, scores on the ADAS-cog for both the ARICEPT® treatment groups increased, indicating that discontinuation of ARICEPT® resulted in a loss of its treatment effect. The duration of this placebo washout period was not sufficient to characterize the rate of loss of the treatment effect, but, the 30-week study (see above) demonstrated that treatment effects associated with the use of ARICEPT® abate within 6 weeks of treatment discontinuation.

Figure 5 illustrates the cumulative percentages of patients from each of the three treatment groups who attained the measure of improvement in ADAS-cog score shown on the X axis. The same three change scores, (7-point and 4-point reductions from baseline or no change in score) as selected for the 30-week study have been used for this illustration. The percentages of patients achieving those results are shown in the inset table.

As observed in the 30-week study, the curves demonstrate that patients assigned to either placebo or to ARICEPT® have a wide range of responses, but that the ARICEPT® treated patients are more likely to show the greater improvements in cognitive performance.

Aricept Figure 5

Effects on the CIBIC plus: Figure 6 is a histogram of the frequency distribution of CIBIC plus scores attained by patients assigned to each of the three treatment groups who completed 12 weeks of treatment. The differences in mean scores for ARICEPT® treated patients compared to the patients on placebo at Week 12 were 0.36 and 0.38 units for the 5 mg/day and 10 mg/day treatment groups, respectively. These differences were statistically significant.

In both studies, patient age, sex and race were not found to predict the clinical outcome of ARICEPT® treatment.

Clinical Pharmacokinetics

ARICEPT® ODT is bioequivalent to ARICEPT® Tablets. Donepezil is well absorbed with a relative oral bioavailability of 100% and reaches peak plasma concentrations in 3 to 4 hours. Pharmacokinetics are linear over a dose range of 1-10 mg given once daily. Neither food nor time of administration (morning vs. evening dose) influences the rate or extent of absorption of ARICEPT® Tablets. A food effect study has not been conducted with ARICEPT® ODT, however, the effect of food with ARICEPT® ODT is expected to be minimal. ARICEPT® ODT can be taken without regard to meals.

The elimination half life of donepezil is about 70 hours and the mean apparent plasma clearance (Cl/F) is 0.13 L/hr/kg. Following multiple dose administration, donepezil accumulates in plasma by 4-7 fold and steady state is reached within 15 days. The steady state volume of distribution is 12 L/kg. Donepezil is approximately 96% bound to human plasma proteins, mainly to albumins (about 75%) and alpha1 - acid glycoprotein (about 21%) over the concentration range of 2-1000 ng/mL.

Donepezil is both excreted in the urine intact and extensively metabolized to four major metabolites, two of which are known to be active, and a number of minor metabolites, not all of which have been identified. Donepezil is metabolized by CYP 450 isoenzymes 2D6 and 3A4 and undergoes glucuronidation. Following administration of 14C-labeled donepezil, plasma radioactivity, expressed as a percent of the administered dose, was present primarily as intact donepezil (53%) and as 6-O-desmethyl donepezil (11%), which has been reported to inhibit AChE to the same extent as donepezil in vitro and was found in plasma at concentrations equal to about 20% of donepezil. Approximately 57% and 15% of the total radioactivity was recovered in urine and feces, respectively, over a period of 10 days, while 28% remained unrecovered, with about 17% of the donepezil dose recovered in the urine as unchanged drug.

Special Populations:

Hepatic Disease: In a study of 11 patients with stable alcoholic cirrhosis, the clearance of ARICEPT® was decreased by 20% relative to 11 healthy age and sex matched subjects.

Renal Disease: In a study of 11 patients with moderate to severe renal impairment (ClCr < 18 mL/min/1.73 m2) the clearance of ARICEPT® did not differ from 11 age and sex matched healthy subjects.

Age: No formal pharmacokinetic study was conducted to examine age related differences in the pharmacokinetics of ARICEPT®. However, mean plasma ARICEPT® concentrations measured during therapeutic drug monitoring of elderly patients with Alzheimer's Disease are comparable to those observed in young healthy volunteers.

Gender and Race: No specific pharmacokinetic study was conducted to investigate the effects of gender and race on the disposition of ARICEPT®. However, retrospective pharmacokinetic analysis indicates that gender and race (Japanese and Caucasians) did not affect the clearance of ARICEPT®.

Drug Interactions

Drugs Highly Bound to Plasma Proteins: Drug displacement studies have been performed in vitro between this highly bound drug (96%) and other drugs such as furosemide, digoxin, and warfarin. ARICEPT® at concentrations of 0.3-10 mg/mL did not affect the binding of furosemide (5 mg/mL), digoxin (2 ng/mL), and warfarin (3 mg/mL) to human albumin. Similarly, the binding of ARICEPT® to human albumin was not affected by furosemide, digoxin and warfarin.

Effect of ARICEPT® on the Metabolism of Other Drugs: No in vivo clinical trials have investigated the effect of ARICEPT® on the clearance of drugs metabolized by CYP 3A4 (e.g. cisapride, terfenadine) or by CYP 2D6 (e.g. imipramine). However, in vitro studies show a low rate of binding to these enzymes (mean Ki about 50-130 mM), that, given the therapeutic plasma concentrations of donepezil (164 nM), indicates little likelihood of interference.

Whether ARICEPT® has any potential for enzyme induction is not known.

Formal pharmacokinetic studies evaluated the potential of ARICEPT® for interaction with theophylline, cimetidine, warfarin, digoxin and ketoconazole. No effects of ARICEPT® on the pharmacokinetics of these drugs were observed.

Effect of Other Drugs on the Metabolism of ARICEPT®: Ketoconazole and quinidine, inhibitors of CYP450, 3A4 and 2D6, respectively, inhibit donepezil metabolism in vitro. Whether there is a clinical effect of quinidine is not known. In a 7-day crossover study in 18 healthy volunteers, ketoconazole (200 mg q.d.) increased mean donepezil (5 mg q.d.) concentration (AUC0-24 and Cmax) by 36%. The clinical relevance of this increase in concentration is unknown.

Inducers of CYP 2D6 and CYP 3A4 (e.g., phenytoin, carbamazepine, dexamethasone, rifampin, and phenobarbital) could increase the rate of elimination of ARICEPT®.

Formal pharmacokinetic studies demonstrated that the metabolism of ARICEPT® is not significantly affected by concurrent administration of digoxin or cimetidine.

Indications and Usage

ARICEPT® is indicated for the treatment of mild to moderate dementia of the Alzheimer's type.

Contraindications

ARICEPT® is contraindicated in patients with known hypersensitivity to donepezil hydrochloride or to piperidine derivatives.

Warnings

Anesthesia: ARICEPT®, as a cholinesterase inhibitor, is likely to exaggerate succinylcholine-type muscle relaxation during anesthesia.

Cardiovascular Conditions: Because of their pharmacological action, cholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes. This effect may manifest as bradycardia or heart block in patients both with and without known underlying cardiac conduction abnormalities. Syncopal episodes have been reported in association with the use of ARICEPT®.

Gastrointestinal Conditions: Through their primary action, cholinesterase inhibitors may be expected to increase gastric acid secretion due to increased cholinergic activity. Therefore, patients should be monitored closely for symptoms of active or occult gastrointestinal bleeding, especially those at increased risk for developing ulcers, e.g., those with a history of ulcer disease or those receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDS). Clinical studies of ARICEPT® have shown no increase, relative to placebo, in the incidence of either peptic ulcer disease or gastrointestinal bleeding.

ARICEPT®, as a predictable consequence of its pharmacological properties, has been shown to produce diarrhea, nausea and vomiting. These effects, when they occur, appear more frequently with the 10 mg/day dose than with the 5 mg/day dose. In most cases, these effects have been mild and transient, sometimes lasting one to three weeks, and have resolved during continued use of ARICEPT®.

Genitourinary: Although not observed in clinical trials of ARICEPT®, cholinomimetics may cause bladder outflow obstruction.

Neurological Conditions: Seizures: Cholinomimetics are believed to have some potential to cause generalized convulsions. However, seizure activity also may be a manifestation of Alzheimer's Disease.

Pulmonary Conditions: Because of their cholinomimetic actions, cholinesterase inhibitors should be prescribed with care to patients with a history of asthma or obstructive pulmonary disease.

Precautions

Drug-Drug Interactions (see Clinical Pharmacology: Clinical Pharmacokinetics: Drug-drug Interactions)

Effect of ARICEPT® on the Metabolism of Other Drugs: No in vivo clinical trials have investigated the effect of ARICEPT® on the clearance of drugs metabolized by CYP 3A4 (e.g. cisapride, terfenadine) or by CYP 2D6 (e.g. imipramine). However, in vitro studies show a low rate of binding to these enzymes (mean Ki about 50-130 mM), that, given the therapeutic plasma concentrations of donepezil (164 nM), indicates little likelihood of interference.

Whether ARICEPT® has any potential for enzyme induction is not known.

Formal pharmacokinetic studies evaluated the potential of ARICEPT® for interaction with theophylline, cimetidine, warfarin, digoxin and ketoconazole. No effects of ARICEPT® on the pharmacokinetics of these drugs were observed.

Effect of Other Drugs on the Metabolism of ARICEPT®: Ketoconazole and quinidine, inhibitors of CYP450, 3A4 and 2D6, respectively, inhibit donepezil metabolism in vitro. Whether there is a clinical effect of quinidine is not known. In a 7-day crossover study in 18 healthy volunteers, ketoconazole (200mg q.d.) increased mean donepezil (5mg q.d.) concentrations (AUC0-24 and Cmax) by 36%. The clinical relevance of this increase in concentration is unknown.

Inducers of CYP 2D6 and CYP 3A4 (e.g., phenytoin, carbamazepine, dexamethasone, rifampin, and phenobarbital) could increase the rate of elimination of ARICEPT®.

Formal pharmacokinetic studies demonstrated that the metabolism of ARICEPT® is not significantly affected by concurrent administration of digoxin or cimetidine.

Use with Anticholinergics: Because of their mechanism of action, cholinesterase inhibitors have the potential to interfere with the activity of anticholinergic medications.

Use with Cholinomimetics and Other Cholinesterase Inhibitors: A synergistic effect may be expected when cholinesterase inhibitors are given concurrently with succinylcholine, similar neuromuscular blocking agents or cholinergic agonists such as bethanechol.

Carcinogenesis, Mutagenesis, Impairment of Fertility

No evidence of a carcinogenic potential was obtained in an 88-week carcinogenicity study of donepezil hydrochloride conducted in CD-1 mice at doses up to 180 mg/kg/day (approximately 90 times the maximum recommended human dose on a mg/m2 basis), or in a 104-week carcinogenicity study in Sprague-Dawley rats at doses up to 30mg/kg/day (approximately 30 times the maximum recommended human dose on a mg/m2 basis).

Donepezil was not mutagenic in the Ames reverse mutation assay in bacteria, or in a mouse lymphoma forward mutation assay in vitro. In the chromosome aberration test in cultures of Chinese hamster lung (CHL) cells, some clastogenic effects were observed. Donepezil was not clastogenic in the in vivo mouse micronucleus test and was not genotoxic in an in vivo unscheduled DNA synthesis assay in rats.

Donepezil had no effect on fertility in rats at doses up to 10 mg/kg/day (approximately 8 times the maximum recommended human dose on a mg/m2 basis).

Pregnancy

Pregnancy Category C: Teratology studies conducted in pregnant rats at doses up to 16 mg/kg/day (approximately 13 times the maximum recommended human dose on a mg/m2 basis) and in pregnant rabbits at doses up to 10 mg/kg/day (approximately 16 times the maximum recommended human dose on a mg/m2 basis) did not disclose any evidence for a teratogenic potential of donepezil. However, in a study in which pregnant rats were given up to 10 mg/kg/day (approximately 8 times the maximum recommended human dose on a mg/m2 basis) from day 17 of gestation through day 20 postpartum, there was a slight increase in still births and a slight decrease in pup survival through day 4 postpartum at this dose; the next lower dose tested was 3 mg/kg/day. There are no adequate or well-controlled studies in pregnant women. ARICEPT® should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers

It is not known whether donepezil is excreted in human breast milk. ARICEPT® has no indication for use in nursing mothers.

Pediatric Use

There are no adequate and well-controlled trials to document the safety and efficacy of ARICEPT® in any illness occurring in children.

Geriatric Use

Alzheimer's disease is a disorder occurring primarily in individuals over 55 years of age. The mean age of patients enrolled in the clinical studies with ARICEPT® was 73 years; 80% of these patients were between 65 and 84 years old and 49% of patients were at or above the age of 75. The efficacy and safety data presented in the clinical trials section were obtained from these patients. There were no clinically significant differences in most adverse events reported by patient groups ≥ 65 years old and < 65 years old.

Adverse Reactions

Adverse Events Leading to Discontinuation

The rates of discontinuation from controlled clinical trials of ARICEPT® due to adverse events for the ARICEPT 5 mg/day treatment groups were comparable to those of placebo-treatment groups at approximately 5%. The rate of discontinuation of patients who received 7-day escalations from 5 mg/day to 10 mg/day, was higher at 13%.

The most common adverse events leading to discontinuation, defined as those occurring in at least 2% of patients and at twice the incidence seen in placebo patients, are shown in Table 1.

Table 1. Most Frequent Adverse Events Leading to Withdrawal
from Controlled Clinical Trials by Dose Group

Dose Group

Placebo

5 mg/day ARICEPT®

10 mg/day ARICEPT®

Patients Randomized

355

350

315

Event/%Discontinuing

Nausea

1% 1%

3%

Diarrhea

0% <1%

3%

Vomiting

<1% <1%

2%

Most Frequent Adverse Clinical Events Seen in Association with the Use of ARICEPT®

The most common adverse events, defined as those occurring at a frequency of at least 5% in patients receiving 10 mg/day and twice the placebo rate, are largely predicted by ARICEPT®'s cholinomimetic effects. These include nausea, diarrhea, insomnia, vomiting, muscle cramp, fatigue and anorexia. These adverse events were often of mild intensity and transient, resolving during continued ARICEPT® treatment without the need for dose modification.

There is evidence to suggest that the frequency of these common adverse events may be affected by the rate of titration. An open-label study was conducted with 269 patients who received placebo in the 15 and 30-week studies. These patients were titrated to a dose of 10 mg/day over a 6-week period. The rates of common adverse events were lower than those seen in patients titrated to 10 mg/day over one week in the controlled clinical trials and were comparable to those seen in patients on 5 mg/day.

See Table 2 for a comparison of the most common adverse events following one and six week titration regimens.

Table 2. Comparison of rates of adverse events in patients
titrated to 10 mg/day over 1 and 6 weeks

 

No titration

One week titration

Six week titration

Adverse Event

Placebo (n=315)

5 mg/day (n=311)

10 mg/day (n=315)

10 mg/day (n=269)

Nausea

6%

5%

19%

6%

Diarrhea

5%

8%

15%

9%

Insomnia

6%

6%

14%

6%

Fatigue

3%

4%

8%

3%

Vomiting

3%

3%

8%

5%

Muscle cramps

2%

6%

8%

3%

Anorexia

2%

3%

7%

3%

Adverse Events Reported in Controlled Trials

The events cited reflect experience gained under closely monitored conditions of clinical trials in a highly selected patient population. In actual clinical practice or in other clinical trials, these frequency estimates may not apply, as the conditions of use, reporting behavior, and the kinds of patients treated may differ. Table 3 lists treatment emergent signs and symptoms that were reported in at least 2% of patients in placebo-controlled trials who received ARICEPT® and for which the rate of occurrence was greater for ARICEPT® assigned than placebo-assigned patients. In general, adverse events occurred more frequently in female patients and with advancing age.

Table 3. Adverse Events Reported in Controlled Clinical Trials
in at Least 2% of Patients Receiving ARICEPT® and at a Higher Frequency
than Placebo-treated Patients

Body System/Adverse Event

Placebo

(n=355)

ARICEPT®

(n=747)

Percent of Patients with any Adverse Event

72

74

Body as a Whole
Headache

9

10

Pain, various locations

8

9

Accident

6

7

Fatigue

3

5

Cardiovascular System
Syncope

1

2

Digestive System
Nausea

6

11

Diarrhea

5

10

Vomiting

3

5

Anorexia

2

4

Hemic and Lymphatic System
Ecchymosis

3

4

Metabolic and Nutritional Systems
Weight Decrease

1

3

Musculoskeletal System
Muscle Cramps

2

6

Arthritis

1

2

Nervous System
Insomnia

6

9

Dizziness

6

8

Depression <1

3

Abnormal Dreams

0

3

Somnolence <1

2

Urogenital System
Frequent Urination

1

2

Other Adverse Events Observed During Clinical Trials

ARICEPT® has been administered to over 1700 individuals during clinical trials worldwide. Approximately 1200 of these patients have been treated for at least 3 months and more than 1000 patients have been treated for at least 6 months. Controlled and uncontrolled trials in the United States included approximately 900 patients. In regards to the highest dose of 10 mg/day, this population includes 650 patients treated for 3 months, 475 patients treated for 6 months and 116 patients treated for over 1 year. The range of patient exposure is from 1 to 1214 days.

Treatment emergent signs and symptoms that occurred during 3 controlled clinical trials and two open-label trials in the United States were recorded as adverse events by the clinical investigators using terminology of their own choosing. To provide an overall estimate of the proportion of individuals having similar types of events, the events were grouped into a smaller number of standardized categories using a modified COSTART dictionary and event frequencies were calculated across all studies. These categories are used in the listing below. The frequencies represent the proportion of 900 patients from these trials who experienced that event while receiving ARICEPT®. All adverse events occurring at least twice are included, except for those already listed in Tables 2 or 3, COSTART terms too general to be informative, or events less likely to be drug caused. Events are classified by body system and listed using the following definitions: frequent adverse events - those occurring in 1/100 patients; infrequent adverse events - those occurring in 1/100 to 1/1000 patients. These adverse events are not necessarily related to ARICEPT® treatment and in most cases were observed at a similar frequency in placebo-treated patients in the controlled studies. No important additional adverse events were seen in studies conducted outside the United States.

Body as a Whole: Frequent: influenza, chest pain, toothache; Infrequent: fever, edema face, periorbital edema, hernia hiatal, abscess, cellulitis, chills, generalized coldness, head fullness, listlessness.

Cardiovascular System: Frequent: hypertension, vasodilation, atrial fibrillation, hot flashes, hypotension; Infrequent: angina pectoris, postural hypotension, myocardial infarction, AV block (first degree), congestive heart failure, arteritis, bradycardia, peripheral vascular disease, supraventricular tachycardia, deep vein thrombosis.

Digestive System: Frequent: fecal incontinence, gastrointestinal bleeding, bloating, epigastric pain; Infrequent: eructation, gingivitis, increased appetite, flatulence, periodontal abscess, cholelithiasis, diverticulitis, drooling, dry mouth, fever sore, gastritis, irritable colon, tongue edema, epigastric distress, gastroenteritis, increased transaminases, hemorrhoids, ileus, increased thirst, jaundice, melena, polydipsia, duodenal ulcer, stomach ulcer.

Endocrine System: Infrequent: diabetes mellitus, goiter.

Hemic and Lymphatic System: Infrequent: anemia, thrombocythemia, thrombocytopenia, eosinophilia, erythrocytopenia.

Metabolic and Nutritional Disorders: Frequent: dehydration; Infrequent: gout, hypokalemia, increased creatine kinase, hyperglycemia, weight increase, increased lactate dehydrogenase.

Musculoskeletal System: Frequent: bone fracture; Infrequent: muscle weakness, muscle fasciculation.

Nervous System: Frequent: delusions, tremor, irritability, paresthesia, aggression, vertigo, ataxia, increased libido, restlessness, abnormal crying, nervousness, aphasia; Infrequent: cerebrovascular accident, intracranial hemorrhage, transient ischemic attack, emotional lability, neuralgia, coldness (localized), muscle spasm, dysphoria, gait abnormality, hypertonia, hypokinesia, neurodermatitis, numbness (localized), paranoia, dysarthria, dysphasia, hostility, decreased libido, melancholia, emotional withdrawal, nystagmus, pacing.

Respiratory System: Frequent: dyspnea, sore throat, bronchitis; Infrequent: epistaxis, post nasal drip, pneumonia, hyperventilation, pulmonary congestion, wheezing, hypoxia, pharyngitis, pleurisy, pulmonary collapse, sleep apnea, snoring.

Skin and Appendages: Frequent: pruritus, diaphoresis, urticaria; Infrequent: dermatitis, erythema, skin discoloration, hyperkeratosis, alopecia, fungal dermatitis, herpes zoster, hirsutism, skin striae, night sweats, skin ulcer.

Special Senses: Frequent: cataract, eye irritation, vision blurred; Infrequent: dry eyes, glaucoma, earache, tinnitus, blepharitis, decreased hearing, retinal hemorrhage, otitis externa, otitis media, bad taste, conjunctival hemorrhage, ear buzzing, motion sickness, spots before eyes.

Urogenital System: Frequent: urinary incontinence, nocturia; Infrequent: dysuria, hematuria, urinary urgency, metrorrhagia, cystitis, enuresis, prostate hypertrophy, pyelonephritis, inability to empty bladder, breast fibroadenosis, fibrocystic breast, mastitis, pyuria, renal failure, vaginitis.

Postintroduction Reports

Voluntary reports of adverse events temporally associated with ARICEPT® that have been received since market introduction that are not listed above, and that there is inadequate data to determine the causal relationship with the drug include the following: abdominal pain, agitation, cholecystitis, confusion, convulsions, hallucinations, heart block (all types), hemolytic anemia, hepatitis, hyponatremia, neuroleptic malignant syndrome, pancreatitis, and rash.

Overdose

Because strategies for the management of overdose are continually evolving, it is advisable to contact a Poison Control Center to determine the latest recommendations for the management of an overdose of any drug.

As in any case of overdose, general supportive measures should be utilized. Overdosage with cholinesterase inhibitors can result in cholinergic crisis characterized by severe nausea, vomiting, salivation, sweating, bradycardia, hypotension, respiratory depression, collapse and convulsions. Increasing muscle weakness is a possibility and may result in death if respiratory muscles are involved. Tertiary anticholinergics such as atropine may be used as an antidote for ARICEPT® overdosage. Intravenous atropine sulfate titrated to effect is recommended: an initial dose of 1.0 to 2.0 mg IV with subsequent doses based upon clinical response. Atypical responses in blood pressure and heart rate have been reported with other cholinomimetics when co-administered with quaternary anticholinergics such as glycopyrrolate. It is not known whether ARICEPT® and/or its metabolites can be removed by dialysis (hemodialysis, peritoneal dialysis, or hemofiltration).

Dose-related signs of toxicity in animals included reduced spontaneous movement, prone position, staggering gait, lacrimation, clonic convulsions, depressed respiration, salivation, miosis, tremors, fasciculation and lower body surface temperature.

Dosage and Administration

The dosages of ARICEPT® shown to be effective in controlled clinical trials are 5 mg and 10 mg administered once per day.

The higher dose of 10 mg did not provide a statistically significantly greater clinical benefit than 5 mg. There is a suggestion, however, based upon order of group mean scores and dose trend analyses of data from these clinical trials, that a daily dose of 10 mg of ARICEPT® might provide additional benefit for some patients. Accordingly, whether or not to employ a dose of 10 mg is a matter of prescriber and patient preference.

Evidence from the controlled trials indicates that the 10 mg dose, with a one week titration, is likely to be associated with a higher incidence of cholinergic adverse events than the 5 mg dose. In open label trials using a 6 week titration, the frequency of these same adverse events was similar between the 5 mg and 10 mg dose groups. Therefore, because steady state is not achieved for 15 days and because the incidence of untoward effects may be influenced by the rate of dose escalation, treatment with a dose of 10 mg should not be contemplated until patients have been on a daily dose of 5 mg for 4 to 6 weeks.

ARICEPT® should be taken in the evening, just prior to retiring. ARICEPT® can be taken with or without food.

Allow ARICEPT® ODT tablet to dissolve on the tongue and follow with water.

How Supplied

ARICEPT® is supplied as film-coated, round tablets containing either 5 mg or 10 mg of donepezil hydrochloride.

The 5 mg tablets are white. The strength, in mg (5), is debossed on one side and ARICEPT is debossed on the other side.

The 10 mg tablets are yellow. The strength, in mg (10), is debossed on one side and ARICEPT is debossed on the other side.

5 mg (White)
Bottles of 30 (NDC# 62856-245-30)
Bottles of 90 (NDC# 62856-245-90)
Unit Dose Blister Package 100 (10x10) (NDC# 62856-245-41)

10 mg (Yellow)
Bottles of 30 (NDC# 62856-246-30)
Bottles of 90 (NDC# 62856-246-90)
Unit Dose Blister Package 100 (10x10) (NDC# 62856-246-41)

ARICEPT® ODT is supplied as tablets containing either 5mg or 10mg of donepezil hydrochloride.

The 5 mg orally disintegrating tablets are white. The strength, in mg (5), is embossed on one side and ARICEPT is embossed on the other side.

The 10 mg orally disintegrating tablets are yellow. The strength, in mg (10), is embossed on one side and ARICEPT is embossed on the other side.

5 mg (White)
Unit Dose Blister Package 30 (10x3) (NDC# 62856-831-30)

10 mg (Yellow)
Unit Dose Blister Package 30 (10x3) (NDC# 62856-832-30)

Storage: Store at controlled room temperature, 15°C to 30°C (59°F to 86°F).

RX only

ARICEPT® is a registered trademark of
Eisai Co., Ltd.
Manufactured and Marketed by Eisai Inc., Teaneck, NJ 07666
Marketed by Pfizer Inc., New York, NY 10017

ARICEPT® (donepezil HCl) is a registered trademark of Eisai Co., Ltd. Privacy/Legal Notices. Copyright(C) 2000 Eisai Inc. and Pfizer Inc. All rights reserved. ARICEPT® (donepezil HCl) is indicated for the treatment of symptoms of mild to moderate Alzheimer's disease.

ARICEPT® (donepezil HCl) is well tolerated but may not be for everyone. Some people may experience nausea, diarrhea, insomnia, vomiting, muscle cramps, fatigue or loss of appetite. In studies, these side effects were usually mild and temporary. Some people taking ARICEPT® (donepezil HCl) may experience fainting. People at risk for ulcers should tell their doctors because their condition may get worse.

This web site may contain information relating to various medical conditions and their treatment. Such information is provided for educational purposes only and is not meant to be a substitute for the advice of a physician or other health care professional. You should not use this information for diagnosing a health problem or disease. In order for you to make intelligent health care decisions, you should always consult with your physician or other health care provider for your personal medical needs.

Aricept patient information (in plain English)

IMPORTANT: The information in this monograph is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects. This information is generalized and is not intended as specific medical advice. If you have questions about the medicines you are taking or would like more information, check with your doctor, pharmacist, or nurse. Last updated 11/06.

Source: Pfizer, U.S. distributor of Aricept.

back to: Psychiatric Medications Pharmacology Homepage

APA Reference
Staff, H. (2008, December 3). Aricept: Cholinesterase Inhibitor, HealthyPlace. Retrieved on 2024, October 5 from https://www.healthyplace.com/alzheimers/medications/aricept-cholinesterase-inhibitor

Last Updated: January 15, 2019

A Room With A View

Essays and Quotes for the Mind and Spirit

"I think maybe needy people are just people who don't feel needed. Well, I say to you: Feel needed. Feel needed because you are." Daniel Quinn

WORDS TO SUCCEED BY:

  • "To laugh often and much;
  • To win the respect of intelligent peopleand the affection of children;
  • to earn the appreciation of honest criticsand endure the betrayal of false friends:
  • To appreciate beauty;
  • To find the best in others;
  • To leave the world a bit better,whether by a healthy child, a garden patchor a redeemed social condition;
  • To know even one life has breathed easierbecause you have lived;
  • This is to have succeeded."

Written by Ralph Waldo Emerson

TEN LAWS OF WELL-BEING

  1. Welcome
  2. Engage
  3. Learn
  4. Laugh
  5. Be
  6. Express
  7. Invent
  8. Nurture
  9. Give
  10. AND LOVE

1.Welcome

Welcome every day that you possibly can as a gift. Take time to appreciate the vast and varied pleasures which make up your life - warm drinks, sunshine, music, the face of a loved one, flowers, inviting scents, a loving touch, a gentle breeze... Take a few moments to breathe deeply and to experience gratitude. Acknowledge the lessons in even painful experiences - for they are often our most powerful teachers.


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2. Engage

Engage in activities that foster emotional, physical, and spiritual well-being. Too often we allow ourselves to get so caught up in the details that we fail to provide ourselves with the necessary ingredients that make up a balanced and meaningful life. When we deprive ourselves of what we truly need, it's easy to begin to perceive life as a struggle rather than a precious journey.

Engage in meaningful contact with others, engage in the moment, and engage all your senses. To engage is to promise, promise yourself the gift of your life.

3. Learn

Life consists of one lesson after another. Pay attention to them when they present themselves, even when it hurts. When we learn - we deepen and empower ourselves, and we expand our horizons. Learning diminishes limits and widens our trail. In general, those who live to learn - live longest.

4. Laugh

Laugh often and loudly. Laughter improves the immune system, relieves stress and lightens burdens.

5. Be

Be where you are this minute, not lost in tomorrow or yesterday. While plans and goals can be important; and reflection may offer wisdom, it's the now that guarantees - only the now that pledges itself to you. The past has left you, the future eludes you, yet the now enfolds you. Embrace it. You're already in its arms, allow it to cradle you.


6. Express

Express yourself. You're unique, imperfect, wonderful, complicated, and evolving. Allow yourself to be who you are even as you work to grow and change. Don't hide yourself away. Share your feelings and dreams with those who are trustworthy. There's so much of you - plenty to go around, and like all that exists in abundance, if it's not shared, it wastes away.

7. Invent

Life is perhaps the most magical when we choose to create. Create as many meaningful experiences as possible, look at the world with your own unique eyes, recognize and accept your ability and responsibility to shape moments, days - your life. Invent and reinvent your life story - it belongs solely to you, enliven it with spirit.

8. Nurture

Nurture your body, your mind, and your soul. Don't starve them or pollute them. Acknowledge that inside of you there exists an unimaginable world, filled with mystery and magic, one that's vast and complex, magnificent and yet vulnerable. You are truly a work of art, a miracle, honor the world which is you.

9. Give

Give to those that share your world - both the inner and outer inhabitants. Give your body what it requires, give your emotional life what it needs, give your spiritual self what it must have, and give to others what they too deserve.

Care for and share with all of your brothers and sisters. Remind yourself that just as the earth is round and can't be seen from both sides unless you're standing above it, there's also much about the world of others which eludes you, thus making it difficult for you to completely understand, and impossible to judge.

Give freely. Give without expectations. Give to yourself.


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10. Love

Love well and love long. While Love can wound it also heals. Love requires much and offers more.

Written by Tammie Byram Fowles

The Rules for Being Human

"1. You will receive a body. You may like it or hate it, but it's the only thing you are sure to keep for the rest of your life.

2. You will learn lessons. You are enrolled in a full-time informal school called, "Life on Planet Earth."

3. There are no mistakes, only lessons. Growth is a process of experimentation. "Failures" are as much a part of the process as "success."

4. A lesson is repeated until learned. It is presented to you in various forms until you learn it -- then you can go on to the next lesson.

5. If you don't learn easy lessons, they get harder. External problems are a precise reflection of your internal state. When you clear inner obstructions, your outside world changes. Pain is how the universe gets your attention.

6. You will know you've learned a lesson when your actions change. Wisdom is practice. A little of something is better than a lot of nothing.

7. "There" is no better "here." When your "there" becomes a "here" you will simply obtain another "there" that again looks better than "here."

8. Others are only mirrors of you. You cannot love or hate something about another unless it reflects something you love or hate in yourself.

9. Your life is up to you. Life provides the canvas; you do the painting. Take charge of your life -- or someone else will.

10. You always get what you want. Your subconscious rightfully determines what energies, experiences, and people you attract -- therefore, the only foolproof way to know what you want is to see what you have...

11. There is no right or wrong, but there are consequences. Moralizing doesn't help. Judgements only hold the patterns in place. Just do your best.

12. Your answers lie inside you. Children need guidance from others; as we mature, we trust our hearts, where the Laws of Spirit are written. You know more than you have heard or read or been told. All you need to do is to look, listen, and trust.

13. You will forget all this.

14. You can remember any time you wish."

author unknown


The True Joy of Life:

"This is the true joy of life, the being used for a purpose recognized by yourself as a mighty one; the being a force of nature instead of a feverish selfish little clod of ailment and grievance complaining that the world will not devote itself to making you happy. I am of the opinion that my life belongs to the whole community and as long as I live it is my privilege to do for it what I can. I want to be used up when I die, for the harder I work the more I live, and I rejoice in life for its own sake. Life is no "brief candle" to me. It is a sort of splendid torch which I have got hold of for the moment, and I want to make it burn as brightly as possible before passing it on to future generations."

Written by George Bernard Shaw

On Hope...

Hope is a state of mind, not of the world. Either we have hope or we don't; it is a dimension of the soul, and it's not essentially dependent on some particular observation of the world or estimate of the situation. Hope is not prognostication. It is an orientation of the spirit, and orientation of the heart; it transcends the world that is immediately experienced, and is anchored somewhere beyond its horizons ...Hope, in this deep and powerful sense, is not the same as joy that things are going well, or willingness to invest in enterprises that are obviously heading for success, but rather an ability to work for something because it is good, not just because it stands a chance to succeed. The more propitious the situation in which we demonstrate hope, the deeper the hope is. Hope is definitely not the same thing as optimism. It is not the conviction that something will turn out well, but the certainty that something makes sense, regardless of how it turns out.

Written by Vaclav Havel


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ON GIVING

Then said a rich man, Speak to us of Giving.
And he answered:

You give but little when you give of your
possessions.
It is when you give of yourself that you
truly give.

For what are your possessions but things
you keep and guard
for fear you may need them tomorrow?
And tomorrow, what shall tomorrow
bring to the over prudent dog
burying bones in the trackless sand as he follows the
to the holy city?
And what if fear of need but need itself?
Is not dread of thirst when your well is full,
the thirst that is unquenchable?

There are those who give little
of the much which they have-
and they give it
for recognition and their hidden desire
makes their gifts unwholesome.
And there are those who have little and give it all.
These are the believers in life and the bounty of life,
and their coffer is never empty.
There are those who give with joy,
and their joy is their reward.
And there are those who give with pain,
and that pain is their baptism.
And there are those who give and know not
pain in giving, nor so they seek joy,
nor give with mindfulness of virtue:
They give as in yonder valley the myrtle
breathes its fragrance into space.
Through the hands of such as these God
speaks, and from behind their eyes
He smiles upon the earth.

It is well to give when when asked, but it is
better to give unasked, through understanding:
And to the open-handed the search for
one who shall receive is joy greater than giving.
And is there ought you would withhold?
All you have shall some day be given:
Therefore give now, that the season of
giving may be yours and not your inheritors`.

You often say, "I would give, but only to the deserving."
The trees in your orchard say not so,
nor the flocks in your pasture.
They give that they may live,
for to with-hold is to perish.
Surely he who is worthy to receive his
days and nights, is worthy of all else from you.
And he who has deserved to drink from
the ocean of life deserves to fill his cup from your little stream.
And what desert greater shall there be,
than that, which lies in the courage and the
confidence, nay the charity, of receiving?
And who are you that men should rend
their bosom and unveil their pride,
that you may see their worth naked and their pride unabashed?
See first that you yourself deserve to be
a giver, and an instrument of giving.

For in truth it is life that gives unto life-
while you, who deem yourself a giver are but a witness.

And you receivers- and you are all
receivers- assume no weight of gratitude,
lest you lay a yoke upon
yourself and upon he who gives.
Rather rise together with the giver on his gifts as on wings:
For to be over mindful of your debt, is
to doubt his generosity who has the
free-hearted earth for mother, and God for father

Written by Kahil Gibran

No one person has to do it all but if each one of us follow our heart and our own inclinations we will find the small things that we can do to create a sustainable future and a healthy environment.

John Denver

next:Patiently Wild

APA Reference
Staff, H. (2008, December 3). A Room With A View, HealthyPlace. Retrieved on 2024, October 5 from https://www.healthyplace.com/alternative-mental-health/sageplace/a-room-with-a-view

Last Updated: July 18, 2014

Therapeutic Touch for Psychological Disorders

14 Therapeutic touch healthyplace

Learn about therapeutic touch as a treatment option for anxiety, stress, Alzheimer's dementia and other psychiatric disorders and fibromyalgia pain.

Before engaging in any complementary medical technique, you should be aware that many of these techniques have not been evaluated in scientific studies. Often, only limited information is available about their safety and effectiveness. Each state and each discipline has its own rules about whether practitioners are required to be professionally licensed. If you plan to visit a practitioner, it is recommended that you choose one who is licensed by a recognized national organization and who abides by the organization's standards. It is always best to speak with your primary health care provider before starting any new therapeutic technique.

Background

Therapeutic touch (TT) was developed by Delores Krieger, R.N., Ph.D., and Dora Kunz, a natural healer, in the early 1970s. Therapeutic touch is a modern adaptation of several religious and secular healing traditions and is most commonly used in nursing practice for a wide range of health conditions.

When administering treatment, therapeutic touch practitioners hold their hands a short distance from a patient, without making physical contact. This technique is believed to help detect a patient's energy field and allows the practitioner to correct any imbalances. A standardized technique is taught by Nurse Healers - Professional Associates, Inc., the primary training organization for therapeutic touch. The treatment protocol consists of a sequence of four steps:

  • Centering — to focus attention on the patient and calm the patient's mind
  • Assessing — to evaluate the patient's energy field for irregularities
  • Intervention — to facilitate symmetrical flow of energy through the patient's energy field
  • Evaluation/closure — to verify the effects and conclude the treatment

 


Treatment sessions typically last five to 20 minutes, but they may take up to 30 minutes. To date, there is no formal certification or competency-based credentialing in therapeutic touch.

Therapeutic touch is taught as a secular approach with no religious connotations, although its core concept of "life energy" or "life force" has sometimes been compared with spiritual rather than scientific principles. Critics have argued that because of its religious roots, therapeutic touch should be treated as a religion rather than as a therapeutic intervention. Skeptics have sought to eliminate therapeutic touch as a nursing practice, based largely on perceived questions surrounding the mechanism of action. Nonetheless, positive results suggested by a few studies in humans, clinical anecdotes and case reports have led to increasing use of therapeutic touch and related practices based on an energetic paradigm.

Since therapeutic touch was first described in the 1970s, several variations have emerged from the original treatment. Healing touch was founded in the 1980s by Janet Mentgen and is based on the principles of therapeutic touch. (The terms therapeutic touch and healing touch are sometimes used interchangeably.) Healing touch focuses on several concepts in addition to those of therapeutic touch, including patient empowerment, practitioner self-care and the effect of the practitioner-patient relationship on healing.

Theory

The mechanism by which therapeutic touch may affect the body is not known. It has been theorized that healing touch affects patients through the connection of energy fields within and outside of the physical body. The treatment of symptoms is thought to occur when the movement of energy stimulates internal mechanisms. Therapeutic touch is asserted to have varying effects on different body systems, with the autonomic nervous system being particularly sensitive. The lymphatic, circulatory and musculoskeletal systems are also thought to be affected. Female endocrine disorders are believed to be more sensitive than male endocrine disorders. Anecdotally, manic and catatonic patients have been reported to respond to therapeutic touch. Most studies of therapeutic touch have examined effects on pain and anxiety.

A controversial study published in the Journal of the American Medical Association in 1998 reported that blindfolded therapeutic touch practitioners were unable to detect which of their hands was closer to the hand of an investigator. The authors concluded that this demonstrated an inability of therapeutic touch practitioners to sense energy fields. The study was later criticized by some therapeutic touch providers who thought that the study did not truly test the clinical applications of touch therapy or assess outcomes such as improved symptoms.


Evidence

Scientists have studied therapeutic touch for the following health problems:

Pain
Several studies suggest that therapeutic touch may reduce pain and improve mobility in patients with osteoarthritis, may decrease pain and anxiety in burn patients and may improve chronic musculoskeletal pain in elderly patients. One study reported a reduced need for pain-relieving drugs after surgery, although overall pain was not reduced. This early research is suggestive. However, most studies have been poor quality, and clear comparisons have not been made with standard pain treatments such as pain-relieving drugs. Most studies have compared therapeutic touch with no therapy or with false (placebo) therapeutic touch. Further study is needed before a firm conclusion can be drawn.

Anxiety
Because of conflicting results of different studies, it is currently unclear if therapeutic touch is useful in the treatment of anxiety. A number of trials have reported benefits, whereas others have found no effects. Most studies have been poorly designed. Scientific analyses taking into account these different studies have not provided clear answers. Better research is necessary before a recommendation can be made.

Psychiatric disorders
There is preliminary evidence that therapeutic touch may help to relax premature infants, reduce anxiety in children with life-threatening illnesses, reduce anxiety in chemically dependent pregnant women, reduce stress and anxiety in the work place, and reduce stress in teen-agers with psychiatric disease. Further study is needed before a recommendation can be made.

Alzheimer's dementia
There is early evidence that therapeutic touch may reduce behavioral symptoms of dementia, such as searching and wandering, tapping and banging, vocalization, anxiety, pacing and agitation. However, larger well-designed studies are needed before a firm conclusion can be drawn.

Headache
A single study reports that therapeutic touch may reduce pain associated with tension headache. However, further research is needed before a recommendation can be made.

Well-being in cancer patients
A single study suggests that therapeutic touch may improve well-being in patients with advanced cancer. Pain, anxiety, depression, and fatigue have been reported as improved in patients receiving therapeutic massage and healing touch. Further research is needed before a recommendation can be made.

Wound healing
Results of the few studies of therapeutic touch for wound healing are mixed, with some reporting improvements, and others showing no effects. Most research has been conducted by the same author. It remains unclear if therapeutic touch has any benefits in wound healing.

Diabetes
One study reports that therapeutic touch does not have significant effects on blood sugar levels in patients with type 1 (insulin-dependent) diabetes mellitus.


 


Fibromyalgia
Preliminary research suggests therapeutic touch may be an effective treatment option in relieving pain in patients with fibromyalgia. Further research is needed before a recommendation can be made.

Unproven Uses

Therapeutic touch has been suggested for many other uses, based on tradition or on scientific theories. However, these uses have not been thoroughly studied in humans, and there is limited scientific evidence about safety or effectiveness. Some of these suggested uses are for conditions that are potentially life-threatening. Consult with a health care provider before using therapeutic touch for any use.

Arthritis
Bone fractures
Bone healing
Cardiovascular disease
Carpal tunnel syndrome
Childbirth preparation
Chronic fatigue syndrome
Depression and acute grief reaction
Dystonia (muscle spasm)
Epilepsy
High blood pressure
Improved flow of breast milk
Multiple sclerosis
Parkinson's disease
Phantom limb pain
Rehabilitation
Sarcoidosis
Sinusitis
Sleep enhancement
Well-being during pregnancy

 


Potential Dangers

Therapeutic touch is believed to be safe in most individuals and does not involve direct physical contact between practitioner and patient. Therapeutic touch should not be used for severe conditions in place of therapies with proven efficacy. There are anecdotal reports of restlessness, anxiety, dizziness, nausea and irritability with therapeutic touch. There is a published case of tension headache and a case of crying associated with therapeutic touch.

Some practitioners believe that therapeutic touch should not be practiced on people during the initial period of a fever or inflammation, and should not be administered to areas of the body with cancer. It is sometimes recommended that treatment sessions for children be shorter than for adults. Also, if the practitioner is emotionally upset, there may be a risk that this emotional upset will transfer from the practitioner to the patient.

Summary

There are few well-designed clinical trials of therapeutic touch. Therapeutic touch remains controversial, and research has not identified a mechanism of action that fits into standard Western models of medicine. There are some treatment areas, such as anxiety and pain, for which there is promising early research. However, there is also some negative evidence, including one study in which blindfolded therapeutic touch practitioners could not sense when they were close to another person's energy field. Better-quality research is needed, because therapeutic touch remains widely used.

The information in this monograph was prepared by the professional staff at Natural Standard, based on thorough systematic review of scientific evidence. The material was reviewed by the Faculty of the Harvard Medical School with final editing approved by Natural Standard.

Resources

  1. Natural Standard: An organization that produces scientifically based reviews of complementary and alternative medicine (CAM) topics
  2. National Center for Complementary and Alternative Medicine (NCCAM): A division of the U.S. Department of Health & Human Services dedicated to research

 


Selected Scientific Studies: Therapeutic Touch

Natural Standard reviewed more than 370 articles to prepare the professional monograph from which this version was created.

Some of the more recent studies are listed below:

  1. Astin JA, Harkness E, Ernst E. The efficacy of "distant healing": a systematic review of randomized trials. Ann Intern Med 2000;132(11):903-910.
  2. Blankfield RP, Sulzmann C, Fradley LG, et al. Therapeutic touch in the treatment of carpal tunnel syndrome. J Am Board Fam Pract 2001;14(5):335-342.
  3. Denison B. Touch the pain away: new research on therapeutic touch and persons with fibromyalgia syndrome. Holist Nurs Pract 2004;18(3):142-151.
  4. Eckes Peck SD. The effectiveness of therapeutic touch for decreasing pain in elders with degenerative arthritis. J Holist Nurs 1997;15(2):176-198.
  5. Giasson M, Bouchard L. Effect of therapeutic touch on the well-being of persons with terminal cancer. J Holist Nurs 1998;16(3):383-398.
  6. Gordon A, Merenstein JH, D'Amico F, et al. The effects of therapeutic touch on patients with osteoarthritis of the knee. J Fam Pract 1998;47(4):271-277.
  7. Ireland M. Therapeutic touch with HIV-infected children: a pilot study. J Assoc Nurses AIDS Care 1998;9(4):68-77.
  8. Lafreniere KD, Mutus B, Cameron S, et al. Effects of therapeutic touch on biochemical and mood indicators in women. J Alt Comp Med 1999;5(4):367-370.
  9. Larden CN, Palmer ML, Janssen P. Efficacy of therapeutic touch in treating pregnant inpatients who have a chemical dependency. J Holist Nurs 2004;22(4):320-332.
  10. Lin Y-S, Taylor AG. Effects of therapeutic touch in reducing pain and anxiety in an elderly population. Integ Med 1998;1(4):155-162.
  11. McElligott D, Holz MB, Carollo L, et al. A pilot feasibility study of the effects of touch therapy on nurses. J N Y State Nurses Assoc 2003;34(1):16-24.
  12. Olson M, Sneed N, LaVia M, et al. Stress-induced immunosuppression and therapeutic touch. Altern Ther Health Med 1997;3(2):68-74. P
  13. eters RM. The effectiveness of therapeutic touch: a meta-analytic review. Nurs Sci Quart 1999;12(1):52-61.
  14. Post-White J, Kinney ME, Savik K, et al. Therapeutic massage and healing touch improve symptoms in cancer. Integr Cancer Ther 2003;2(4):332-344.
  15. Richards K, Nagel C, Markie M, et al. Use of complementary and alternative therapies to promote sleep in critically ill patients. Crit Care Nurs Clin North Am 2003;15(3):329-340.
  16. Rosa L, Rosa E, Sarner L, et al. A close look at therapeutic touch. JAMA 1998;279(13):1005-1010.
  17. Samarel N, Fawcett J, Davis MM, et al. Effects of dialogue and therapeutic touch on preoperative and postoperative experiences of breast cancer surgery: an exploratory study. Oncol Nurs Forum 1998;25(8):1369-1376.
  18. Smith DW, Arnstein P, Rosa KC, Wells-Federman C. Effects of integrating therapeutic touch into a cognitive behavioral pain treatment program: report of a pilot clinical trial. J Holist Nurs 2002;Dec, 20(4):367-387.
  19. Smith MC, Reeder F, Daniel L, et al. Outcomes of touch therapies during bone marrow transplant. Altern Ther Health Med 2003;Jan-Feb, 9(1):40-49.
  20. Turner JG, Clark AJ, Gauthier DK, et al. The effect of therapeutic touch on pain and anxiety in burn patients. J Adv Nurs 1998;28(1):10-20.
  21. Weze C, Leathard HL, Grange J, et al. Evaluation of healing by gentle touch in 35 clients with cancer. Eur J Oncol Nurs 2004;8(1):40-49.
  22. Winstead-Fry P, Kijek J. An integrative review and meta-analysis of therapeutic touch research. Alt Ther Health Med 1999;5(6):58-67.
  23. Wirth DP, Cram JR, Chang RJ. Multisite electromyographic analysis of therapeutic touch and qigong therapy. J Alt Comp Med 1997;3(2):109-118.
  24. Woods DL, Craven RF, Whitney J. The effect of therapeutic touch on behavioral symptoms of persons with dementia. Altern Ther Health Med 2005;11(1):66-74.
  25. Woods DL, Whitney J. The effect of therapeutic touch on disruptive behaviours of individuals with dementia of the Alzheimer type. Alt Ther Health Med 1996;2(4):95-96.
  26. Woods DL, Dimond M. The effect of therapeutic touch on agitated behavior and cortisol in persons with Alzheimer's disease. Biol Res Nurs 2002;Oct, 4(2):104-114.

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APA Reference
Staff, H. (2008, December 3). Therapeutic Touch for Psychological Disorders, HealthyPlace. Retrieved on 2024, October 5 from https://www.healthyplace.com/alternative-mental-health/treatments/therapeutic-touch-for-psychological-disorders

Last Updated: July 10, 2016

TENS (Transcutaneous Electrical Nerve Stimulation)

13 TENS healthyplace

Learn about TENS (Transcutaneous Electrical Nerve Stimulation) as treatment for chronic pain, Alzheimer's disease and ADHD.

Before engaging in any complementary medical technique, you should be aware that many of these techniques have not been evaluated in scientific studies. Often, only limited information is available about their safety and effectiveness. Each state and each discipline has its own rules about whether practitioners are required to be professionally licensed. If you plan to visit a practitioner, it is recommended that you choose one who is licensed by a recognized national organization and who abides by the organization's standards. It is always best to speak with your primary health care provider before starting any new therapeutic technique.

Background

Transcutaneous electrical nerve stimulation (TENS) involves the passage of low-voltage electrical current to electrodes pasted on the skin. The current is delivered through wires from a small battery-powered power unit. The frequency and intensity of this treatment depend on the specific condition and treatment goals. Accordingly, the electrode pads are placed in various sites on the body. Frequency, intensity, and site of application are believed to be pivotal to achieving optimal effects during and after stimulation.

TENS is most commonly used for pain management. There are different types of TENS:

  • Conventional TENS — High- or low-frequency electrical current is applied, often near affected areas.
  • Acupuncture-like TENS — Lower-frequency current is used at specific trigger points.
  • Auricular TENS — Electrical current is applied to the ear

 


Theory

Electricity has been used medicinally for thousands of years. Stone carvings from ancient Egypt depict electric fish being used to treat pain. In ancient Greece, electrogenic torpedo fish were used to treat arthritis and headache.

There are several proposed explanations for how TENS may work:

  • It may affect the nerves that perceive pain or light touch.
  • It may interfere with nerve pathways.
  • It may alter the natural chemicals (such as encephalins, endorphins, opioids or substance P) that affect the way pain is perceived and transmitted.

None of these mechanisms has been clearly demonstrated in scientific research, and the basis of potential activity of TENS is controversial.

Theories traditionally used to explain acupuncture, such as effects on flow of vital energy, have also been offered to explain TENS. It is sometimes suggested that TENS may affect the cardiovascular system, increasing heart rate and reducing blood pressure.


Evidence

Scientists have studied TENS for the following health problems:

Dental procedure pain: Several small studies report that various TENS techniques reduce pain and the need for pain medications during dental procedures. TENS may also be useful in relieving pain associated with mandibular fractures. Because of problems with the quality of these trials, this evidence can be considered only preliminary. Better research is necessary to make a strong recommendation.

Knee osteoarthritis" Multiple trials report improvements in knee stiffness, physical performance, range of motion, and pain in patients with knee osteoarthritis treated with TENS. It is not clear that TENS improves walking distance or swelling. Some of these studies are small and are not of high-quality. Better research is needed to make a strong recommendation.

Anesthesia (pain relief during surgery): Auricular TENS is sometimes used in Europe to reduce the need for anesthesia during surgical procedures. There is not enough reliable evidence to make a recommendation.

Alzheimer's disease: A small amount of early research reports that TENS may improve some symptoms of Alzheimer's disease, such as mood, memory and cycles of daily rest and activity. Better studies are necessary to make a conclusion.

Angina (chest pain from heart disease): Several small, brief studies (mostly from the 1980s and 1990s) report benefits of TENS on angina pectoris, but most were not well designed or reported. It has been suggested that TENS may improve exercise tolerance and measures of ischemia but not improve symptoms. People with heart disease or chest pain are advised to seek immediate medical attention from a licensed physician. Many well-studied drugs for heart disease are available. Further study is needed before conclusions can be drawn regarding the effectiveness of TENS in this area.

Ankylosing spondylitis: Early research does not provide enough scientific evidence to draw a firm conclusion about effectiveness.

Back pain: The use of conventional TENS or acupuncture-like TENS in people with low back pain is controversial. Studies have used a variety of TENS techniques and defined back pain in different ways. Multiple trials have been published, but most research is not well designed or reported. Overall, it remains unclear if TENS is beneficial. Better-designed research is needed to make a firm conclusion.

Burn pain: Early research does not provide enough scientific evidence to draw a firm conclusion about effectiveness of TENS for burn pain.

Cancer pain: Early research does not provide enough scientific evidence to draw a firm conclusion about effectiveness of TENS for cancer pain.

Chronic pain: The effect of TENS on chronic pain of various causes and locations is controversial. Multiple studies have been published, and even though they have reported benefits, studies have overall been of poor quality. Better-designed research is needed to make a firm conclusion.


 


Dysmenorrhea (painful menstruation): Several small studies report that TENS may reduce short-term discomfort and the need for pain medications. However, this research has not been high-quality overall. Better-designed trials are needed to make a firm conclusion.

Headache: Preliminary studies report that TENS may have some benefits in patients with migraine or chronic headache. However, this research has not been high-quality overall. Better-designed trials are needed to make a firm conclusion.

Hemiplegia, hemiparesis (paralysis on one side of the body): Early research does not provide enough scientific evidence to draw a firm conclusion about effectiveness.

Labor pain: The use of TENS for labor pain is controversial. Multiple studies have been published, but even though they reported a reduced need for pain medications, studies have been small, poorly designed and without clear descriptions of results overall. Better-designed trials are needed to make a firm conclusion. It is not clear if passage of electricity using TENS has harmful effects on the fetus.

Local anesthesia during gallstone lithotripsy: Lithotripsy involves the use of sound waves to break up gallstones. Early research does not provide enough scientific evidence to draw a firm conclusion about effectiveness.

Facial pain, trigeminal neuralgia, bruxism (tooth grinding) pain: Several small studies report benefits when TENS is used to treat chronic facial pain of various causes. However, these trials are not well designed or reported, and additional research is needed to make a firm conclusion.

Myofascial pain: Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness of TENS for myofascial pain.

Pregnancy-related nausea or vomiting: Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness of TENS for pregnancy-related nausea or vomiting.

Neck and shoulder pain: Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness of TENS for neck and shoulder pain.

Pain from broken bones, rib fracture or acute trauma: A randomized controlled trial in 100 patients with minor rib fracture showed TENS therapy to be more effective for relieving pain than were nonsteroidal anti-inflammatory drugs or placebo therapy.

Diabetic peripheral neuropathy: Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness of TENS for peripheral neuropathy.

Phantom limb pain: Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness of TENS in phantom limb pain.

Post-herpetic neuralgia (pain after shingles): Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness of TENS in post-herpetic neuralgia.

Postoperative ileus (bowel obstruction): Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Postoperative nausea or vomiting: Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Postoperative pain: There are multiple studies of TENS being used to treat pain after different types of surgery, including abdominal surgery, heart surgery, lung surgery, gynecologic surgery and orthopedic surgery. Some studies report benefits (less pain, less pain with movement, or less need for pain medications), and others find no improvements. Better-quality research is needed to make a firm conclusion.

Post-stroke rehabilitation: One study on spastic dropped foot in subacute stroke reported that TENS had a beneficial effect. Further research is needed to draw a firm conclusion about effectiveness.

Rheumatoid arthritis: A small number of studies report improved joint function and pain in rheumatoid arthritis patients treated with TENS. However, this research is not well designed or reported, and better studies are needed to make a clear conclusion.

Skin ulcers: Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Spinal cord injury: Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Temporomandibular joint pain: Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Urinary incontinence, overactive bladder, detrusor instability: Several small, poorly designed studies exist. Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Spinal muscular atrophy (in children): One early study in eight children with spinal muscular atrophy reflected unfavorably on TENS therapy. Early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Pain during hysteroscopy: A randomized controlled trial in 142 women undergoing hysteroscopy showed that the group who received TENS therapy experienced a significantly lower level of pain. Further high-quality scientific evidence is needed to draw a firm conclusion about effectiveness.

Gastroparesis: One small study of 38 gastroparesis patients receiving percutaneous electrical nerve stimulation (similar to TENS) reported a reduction in nausea and vomiting and a favorable weight gain after 12 months of therapy on the stomach. It is uncertain if these results would be seen with TENS therapy. This early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Chronic obstructive pulmonary disease rehabilitation: One small randomized controlled trial involving 18 people undergoing rehabilitation for chronic obstructive pulmonary disease (COPD) showed improved muscle strength in the lower extremities as a result of TENS therapy. This suggests that TENS could be useful in adjunct to other components in a rehabilitation program for COPD. This early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Carpal tunnel syndrome: A small, well-designed trial in 11 patients with carpal tunnel syndrome reported that TENS therapy was an effective treatment for pain. This early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Soft tissue injury: A randomized controlled trial examined 60 patients with shoulder tendonitis and the effect of TENS and shock-wave therapy on pain. This study showed shock-wave therapy to be more effective than TENS for this condition. Another randomized trial evaluated burst TENS in Achilles tendon injuries. TENS appeared to be beneficial after suture of the Achilles tendon. Further research is needed to confirm these results.

Multiple sclerosis: In a small randomized controlled trial, patients with multiple sclerosis treated with TENS showed a trend toward improvement. Larger, well-designed studies are needed before conclusions can be drawn.

Intermittent claudication: A small randomized controlled trial suggests chronic electrical muscle stimulation may be beneficial for the relief of intermittent claudication symptoms. Further evidence is needed before drawing a firm conclusion.

Attention-deficit hyperactivity disorder (ADHD): A small randomized controlled trial found a moderate benefit in children with ADHD, but further research is warranted before a firm conclusion can be drawn.

Cognitive impairment: Preliminary evidence reports improvements in mood and mild cognitive impairment in elderly patients who do not suffer from Alzheimer's disease or early dementia. However, this early research does not provide enough high-quality scientific evidence to draw a firm conclusion about effectiveness.

Knee replacement pain: Preliminary evidence has found TENS not to relieve postoperative pain after knee replacement. Further research is needed to confirm these results.

 


Unproven Uses

TENS has been suggested for many uses, based on tradition or on scientific theories. However, these uses have not been thoroughly studied in humans, and there is limited scientific evidence about safety or effectiveness. Some of these suggested uses are for conditions that are potentially life-threatening. Consult with a health care provider before using TENS for any use.

Achalasia
Aging
Antiviral
Atopic eczema
Bursitis
Carpal tunnel syndrome
Dementia
Depression
Dry mouth
Dystonia
Enhanced blood flow in the brain
Enhanced blood perfusion of the uterus and placenta
Esophageal spasm
Fibromyalgia
Fracture pain
Guillain-Barre syndrome
Hemophilia
Herpes
High blood pressure
Hip pain
Interstitial cystitis
Irritable bowel syndrome
Itch
Joint pain
Labor induction
Local anesthesia
Menstrual cramps
Muscle cramps
Muscle spasticity
Muscle strain or pain
Musculoskeletal trauma
Myofascial pain dysfunction syndrome
Nerve damage
Osteoarthritis
Pain medication adjunct
Pancreatitis
Pruritus
Raynaud's phenomenon
Repetitive strain injuries
Sacral pain
Schizophrenia
Shingles
Shoulder subluxation
Sickle cell anemia pain
Skin flap ischemia (during plastic surgery)
Sphincter of Oddi disorders
Sports injuries
Thrombophlebitis
Tinnitus (ringing in the ear)
Tremor
Whiplash

Potential Dangers

In general, TENS is reported as being well tolerated, although research on safety is limited. Skin irritation and redness are the most common side effects, occurring in up to one-third of people. Electrode paste may cause hives, welts or allergic skin reactions (contact dermatitis). Electrical burns may occur with excessive use or improper technique.


 


Because there is a risk of burns, TENS should be used with caution in people with decreased sensation, such as people with neuropathy. TENS should not be used in people with implanted medical devices such as cardiac defibrillators, pacemakers, intravenous infusion pumps or hepatic artery infusion pumps. Electrical shock or device malfunction may occur.

There are isolated reports of several other side effects, including fluid buildup in the lung, partial collapse of the lung, loss of sensation, pain or unpleasant sensations (near or away from the site of TENS), increased hair growth, headache, muscle aches, nausea, agitation and dizziness. It is not clear if TENS caused these problems. Seizures have been reported, and TENS should be used cautiously in people with seizure disorders. It is sometimes suggested that TENS may affect the cardiovascular system, increasing heart rate and reducing blood pressure.

Although multiple studies have used TENS for pain relief during childbirth, evidence about its safety is limited, and a theoretical risk of harm to the fetus exists. Elevations in fetal heart rate and interference with fetal heart monitoring equipment have been reported. This technique should not be used unless under the strict supervision of an experienced licensed health care practitioner. Safety of TENS is not established in children.

Summary

TENS is most commonly used to manage pain, although it has been recommended or studied for many other medical conditions. Preliminary evidence suggests that TENS may be beneficial in the control of dental procedure pain and knee osteoarthritis symptoms. Other uses of TENS have not been sufficiently studied to draw firm conclusions. Skin reactions may occur. People with implanted medical devices should avoid TENS. TENS should be used cautiously and only under medical supervision in pregnant women, children and people with seizure disorders.

The information in this monograph was prepared by the professional staff at Natural Standard, based on thorough systematic review of scientific evidence. The material was reviewed by the Faculty of the Harvard Medical School with final editing approved by Natural Standard.


Resources

  1. Natural Standard: An organization that produces scientifically based reviews of complementary and alternative medicine (CAM) topics
  2. National Center for Complementary and Alternative Medicine (NCCAM): A division of the U.S. Department of Health & Human Services dedicated to research

Selected Scientific Studies: Transcutaneous Electrical Nerve Stimulation

Natural Standard reviewed more than 1,460 articles to prepare the professional monograph from which this version was created.

Some of the more recent studies are listed below:

    1. Abell TL, Van Cutsem E, Abrahamsson H, et al. Gastric electrical stimulation in intractable symptomatic gastroparesis. Digestion 2002;66(4):204-212.
    2. Allais G, De Lorenzo C, Quirico PE, et al. Non-pharmacological approaches to chronic headaches: transcutaneous electrical nerve stimulation, lasertherapy and acupuncture in transformed migraine treatment. Neurol Sci 2003;May, 24(Suppl 2):138-142.
    3. Al-Smadi J, Warke K, Wilson, et al. A pilot investigation of the hypoalgesic effects of transcutaneous electrical nerve stimulation upon low back pain in people with multiple sclerosis. Clin Rehabil 2003;17(7):742-749.
    4. Alvarez-Arenal A, Junquera LM, Fernandez JP, et al. Effect of occlusal splint and transcutaneous electric nerve stimulation on the signs and symptoms of temporomandibular disorders in patients with bruxism. J Oral Rehabil 2002;Sep, 29(9):858-863.

 


  1. Amarenco G, Ismael SS, Even-Schneider A, et al. Urodynamic effect of acute transcutaneous posterior tibial nerve stimulation in overactive bladder. J Urol 2003;Jun, 169(6):2210-2215.
  2. Anderson SI, Whatling P, Hudlicka O, et al. Chronic transcutaneous electrical stimulation of calf muscles improves functional capacity without inducing systemic inflammation in claudicants. Eur J Vasc Endovasc Surg 2004;27(2):201-209.
  3. Benedetti F, Amanzio M, Casadio C, et al. Control of postoperative pain by transcutaneous electrical nerve stimulation after thoracic operations. Ann Thorac Surg 1997;63(3):773-776.
  4. Bloodworth DM, Nguyen BN, Garver W, et al. Comparison of stochastic vs. conventional transcutaneous electrical stimulation for pain modulation in patients with electromyographically documented radiculopathy. Am J Phys Med Rehabil 2004;83(8):584-5591.
  5. Bodofsky E. Treating carpal tunnel syndrome with lasers and TENS. Arch Phys Med Rehabil 2003;83(12):1806-1807.
  6. Bourjeily-Habr G, Rochester CL, Alermo F, et al. Randomised controlled trial of transcutaneous electrical muscle stimulation of the lower extremities in patients with chronic obstructive pulmonary disease. Thorax 2002;Dec, 57(12):1045-1049.
  7. Breit R, Van der Wall H. Transcutaneous electrical nerve stimulation for postoperative pain relief after total knee arthroplasty. J Arthroplasty 2004;19(1):45-48.
  8. Brosseau L, Milne S, Robinson V, et al. Efficacy of the transcutaneous electrical nerve stimulation for the treatment of chronic low back pain: a meta-analysis. Spine 2003;27(6):596-603.
  9. Burssens P, Forsyth R, Steyaert A, et al. Influence of burst TENS stimulation on the healing of Achilles tendon suture in man. Acta Ortho Belg 2003;69(6):528-532.
  10. Campbell TS, Ditto B. Exaggeration of blood pressure-related hypoalgesia and reduction of blood pressure with low frequency transcutaneous electrical nerve stimulation. Psychophysiology 2002;Jul, 39(4):473-481.
  11. Carroll D, Moore RA, McQuay HJ, et al. Transcutaneous electrical nerve stimulation (TENS) for chronic pain (Cochrane Review). Cochrane Database of Systemic Reviews 2001;4.
  12. Carroll D, Tramer M, McQuay H, et al. Transcutaneous electrical nerve stimulation in labour pain: a systematic review. Br J Obstet Gynaecol 1997;104(2):169-175.
  13. Cheing GL, Hui-Chan CW, Chan KM. Does four weeks of TENS and/or isometric exercise produce cumulative reduction of osteoarthritic knee pain? Clin Rehabil 2003;16(7):749-760.
  14. Cheing GL, Hui-Chan CW. Would the addition of TENS to exercise training produce better physical performance outcomes in people with knee osteoarthritis than either interventioin alone. Clin Rehabil 2004;18(5):487-497.
  15. Cheing GL, Tsui AY, Lo SK, et al. Optimal stimulation duration of tens in the management of osteoarthritic knee pain. J Rehabil Med 2003;Mar, 35(2):62-68.
  16. Chesterton LS, Barlas P, Foster NE, et al. Sensory stimulation (TENS): effects of parameter manipulation on mechanical pain thresholds in healthy human subjects. Pain 2002;Sep, 99(1-2):253-262.
  17. Chesterton LS, Foster NE, Wright CC, et al. Effects of TENS frequency, intensity and stimulation site parameter manipulation on pressure pain thresholds in healthy human subjects. Pain 2003;106(1-2):73-80.
  18. Chiu JH, Chen WS, Chen CH, et al. Effect of transcutaneous electrical nerve stimulation for pain relief on patients undergoing hemorrhoidectomy: prospective, randomized, controlled trial. Dis Colon Rectum 1999;42(2):180-185.
  19. Coloma M, White PF, Ogunnaike BO, et al. Comparison of acustimulation and ondansetron for the treatment of established postoperative nausea and vomiting. Anesthesiology 2002;Dec, 97(6):1387-1392.
  20. Cramp FL, McCullough GR, Lowe AS, et al. Transcutaneous electric nerve stimulation: the effect of intensity on local and distal cutaneous blood flow and skin temperature in healthy subjects. Arch Phys Med Rehabil 2002;Jan, 83(1):5-9.
  21. Crevenna R, Posch M, Sochor A, et al. Optimizing electrotherapy: a comparative study of 3 different currents [Article in German]. Wien Klin Wochenschr 2002;Jun 14, 114(10-11):400-404.
  22. De Angelis C, Perrone G, Santoro G, et al. Suppression of pelvic pain during hysteroscopy with a transcutaneous electrical nerve stimulation device. Fertil Steril 2003;Jun, 79(6):1422-1427.
  23. de Tommaso M, Fiore P, Camporeale A, et al. High and low frequency transcutaneous electrical nerve stimulation inhibits nociceptive responses induced by CO2 laser stimulation in humans. Neurosci Lett 2003;May 15, 342(1-2):17-20.
  24. Deyo RA, Walsh NE, Martin DC, et al. A controlled trial of transcutaneous electrical nerve stimulation (TENS) and exercise for chronic low back pain. N Engl J Med 1990;322(23):1627-1634.
  25. Domaille M, Reeves B. TENS and pain control after coronary artery bypass surgery. Physiotherapy 1997;83(10):510-516.
  26. Fagade OO, Obilade TO. Therapeutic effect of TENS on post-IMF trismus and pain. Afr J Med Med Sci 2003;32(4):391-394.
  27. Fehlings DL, Kirsch S, McComas A, et al. Evaluation of therapeutic electrical stimulation to improve muscle strength and function in children with types II/III spinal muscular atrophy. Dev Med Child Neurol 2002;Nov, 44(11):741-744.
  28. Forst T, Nguyen M, Forst S. Impact of low frequency transcutaneous electrical nerve stimulation on symptomatic diabetic neuropathy using a new Salutaris device. Diabetes Nutr Metab 2004;17(3):163-168.
  29. Grant DJ, Bishop-Miller J, Winchester DM, et al. A randomized comparative trial of acupuncture versus transcutaneous electrical nerve stimulation for chronic back pain in the elderly. Pain 1999;82(1):9-13.
  30. Guo Y, Shi X, Uchiyama H, et al. A study on the rehabilitation of cognitive function and short-term memory in patients with Alzheimer's disease using transcutaneous electrical nerve stimulation. Front Med Biol Eng 2002;11(4):237-247.
  31. Hamza MA, White PF, Ahmed HE, et al. Effect of the frequency of transcutaneous electrical nerve stimulation on the post-operative opioid analgesic requirement and recovery profile. Anesth Analg 1999;88:212.
  32. Hardy SG, Spaulding TB, Liu H, et al. The effect of transcutaneous electrical stimulation on spinal motor neuron excitability in people without known neuromuscular diseases: the roles of stimulus intensity and location. Phys Ther 2002;Apr, 82(4):354-363. Erratum in: Phys Ther 2002;May, 82(5):527.
  33. Herman E, Williams R, Stratford P, et al. A randomized controlled trial of transcutaneous electrical nerve stimulation (CODETRON) to determine its benefits in a rehabilitation program for acute occupational low back pain. Spine 1994;19(5):561-568.
  34. Hettrick HH, O'Brien K, Laznick H, et al. Effect of transcutaneous electrical nerve stimulation for the management of burn pruritus: a pilot study. J Burn Care Rehabil 2004;25(3):236-240.
  35. Hou CR, Tsai LC, Cheng KF, et al. Immediate effects of various physical therapeutic modalities on cervical myofascial pain and trigger-point sensitivity. Arch Phys Med Rehabil 2002;Oct, 83(10):1406-1414.
  36. Hsieh RL, Lee WC. One-shot percutaneous electrical nerve stimulation vs. transcutaneous electrical nerve stimulation for low back pain: comparison of therapeutic effects. Am J Phys Med Rehabil 2003;81(11):838-843.
  37. Johansson BB, Haker E, von Arbin M, et al. Acupuncture and transcutaneous nerve stimulation in stroke rehabilitation: a randomized, controlled trial. Stroke 2001;32(3):707-713.
  38. Johnson CA, Wood DE, Swain ID, et al. A pilot study to investigate the combined use of botulinum neurotoxin type a and functional electrical stimulation, with physiotherapy, in the treatment of spastic dropped foot in subacute stroke. Artif Organs 2002;Mar, 26(3):263-266.
  39. Jonsdottir S, Bouma A, Sergeant JA, et al. Effects of transcutaneous electrical stimulation (TENS) on cognition, behavior, and the rest-activity rhythm in children with attention deficit hyperactivity disorder, combined type. Neurorehabil Neural Repair 2004;18(4):212-221.
  40. Koke AJ, Schouten JS, Lamerichs-Geelen MJ, et al. Pain reducing effect of three types of transcutaneous electrical nerve stimulation in patients with chronic pain: a randomized crossover trial. Pain 2004;108(1-2):36-42.
  41. Law PP, Cheing GL. Optimal stimulation frequency of transcutaneous electrical nerve stimulation on people with knee osteoarthritis. J Rehabil Med 2004;36 (5):220-225.
  42. Luijpen MW, Swaab DF, Sergeant JA, et al. Effects of transcutaneous electrical nerve stimulation (TENS) on self-efficacy and mood in elderly with mild cognitive impairment. Neurorehabil Neural Repair 2004;18(3):166-175.
  43. Meechan JG, Gowans AJ, Welbury RR. The use of patient-controlled transcutaneous electronic nerve stimulation (TENS) to decrease the discomfort of regional anaesthesia in dentistry: a randomised controlled clinical trial. J Dent 1998;26(5-6):417-420.
  44. Milne S, Welch V, Brosseau L, et al. Transcutaneous electrical nerve stimulation (TENS) for chronic low back pain (Cochrane Review). Cochrane Database Syst Rev 2001;2:CD003008.
  45. Munhoz RP, Hanajima R, Ashby P, et al. Acute effect of transcutaneous electrical nerve stimulation on tremor. Mov Disord 2003;18(2):191-194.
  46. Murray S, Collins PD, James MA. An investigation ingo the 'carry over' effect of neurostimulation in the treatment of angina pectoris. Int J Clin Pract 2004;58(7):669-674.
  47. Naeser MA, Hahn KA, Lieberman BE, Branco KF. Carpal tunnel syndrome pain treated with low-level laser and microamperes transcutaneous electric nerve stimulation: a controlled study. Arch Phys Med Rehabil 2002;Jul, 83(7):978-988. Comment in: Arch Phys Med Rehabil 2002;Dec, 83(12):1806. Author reply, 1806-1807.
  48. Ng MM Leung MC, Poon DM. The effects of electro-acupuncture and transcutaneous electrical nerve stimulation on patients with painful osteoarthritic knees: a randomized controlled trial with follow-up evaluation. J Altern Complement Med 2003;9(5):641-649.
  49. Okada N, Igawa Y, Ogawa A, et al. Transcutaneous electrical stimulation of thigh muscles in the treatment of detrusor overactivity. Br J Urol 1998;81(4):560-564.
  50. Olyaei GR, Talebian S, Hadian MR, et al. The effect of transcutaneous electrical nerve stimulation on sympathetic skin response. Electromyogr Clin Neurophysiol 2004;44(1):23-28.
  51. Oncel M, Sencan S, Yildiz H, et al. Transcutaneous electrical nerve stimulation for pain management in patients with uncomplicated minor rib fractures. Eur J Cardiothorac Surg 2003;22(1):13-17.
  52. Osiri M, Welch V, V, Brosseau L, et al. Transcutaneous electrical nerve stimulation for knee osteoarthritis (Cochrane Review). Cochrane Database Syst Rev 2000;4:CD002823.
  53. Pan PJ, Chou CL, Chiou HJ, et al. Extracorporeal shock wave therapy for chronic calcific tendinitis of the shoulders: a functional and sonographic study. Arch Phys Med Rehabil 2003;Jul, 84(7):988-993.
  54. Peters EJ, Lavery LA, Armstrong DG, et al. Electric stimulation as an adjunct to heal diabetic foot ulcers: a randomized clinical trial. Arch Phys Med Rehabil 2001;82(6):721-725.
  55. Poletto CJ, Van Doren CL. Elevating pain thresholds in humans using depolarizing prepulses. IEEE Trans Biomed Eng 2002;Oct, 49(10):1221-1224.
  56. Pope MH, Phillips RB, Haugh LD, et al. A prospective randomized three-week trial of spinal manipulation, transcutaneous muscle stimulation, massage and corset in the treatment of subacute low back pain. Spine 1994;19(22):2571-2577.
  57. Price CIM, Pandyan AD. Electrical stimulation for preventing and treating post-stroke shoulder pain (Cochrane Review). Cochrane Database of Systemic Reviews 2001;4:CD001698.
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APA Reference
Staff, H. (2008, December 3). TENS (Transcutaneous Electrical Nerve Stimulation), HealthyPlace. Retrieved on 2024, October 5 from https://www.healthyplace.com/alternative-mental-health/treatments/tens-transcutaneous-electrical-nerve-stimulation

Last Updated: July 10, 2016

We Can Be Heroes

Yes, I've been following all the hoopla surrounding Star Wars: The Phantom Menace. Being an avid fan of the characters, the story, and the mythological connotations, I just had to be among those who saw the movie during its first week. I was quite impressed—the computer-generated graphics are as realistic as I ever seen. I definitely recommend the movie if you want to escape reality for a few hours.

I happened to pick up a copy of the April 26 Time magazine the other day, and of course, it featured an interview with the movie's creator, George Lucas. Here is a quote I took to heart:

"Heroes come in all sizes, and you don't have to be a giant hero. You can be a very small hero. It's just as important to understand that accepting self-responsibility for the things you do, having good manners, caring about other people—these are heroic acts. Everybody has the choice of being a hero or not being a hero every day of their lives. You don't have to get into a giant laser-sword fight and blow up three spaceships to become a hero."

Now that is recovery in a nutshell. As co-dependents, we tried to be giant heroes. We tried to save the universe and everyone in it. We worked hard to convince others that we had their best interests in mind as we sought to control their actions. We talked ourselves blue in the face. We wore ourselves out from all the good we did, all the help we gave so selflessly, and all the advice we dispensed unsolicited.

First, we drove ourselves (and those around us) crazy with our giant heroics. Then we got depressed because no one appreciated us. No one noticed our flashing light saber. No one listened to our words of wisdom.

But in recovery, we have learned to live quietly. We've learned the value of letting go. We detach. We rest. We save the world by saving ourselves. We admit the craziness of seeking to control what we can't. We free ourselves to be ourselves. We free others to be themselves. We revel in today, in the moment, and we let tomorrow take care of itself. We seek to live in harmony with others. We take joy from the tiny surprises of a baby's breathing, a cool breeze on our forehead, or offering a friend a backrub and a hug.

We can take care of ourselves. We can love without becoming enmeshed. We can give without being taken. We can live peacefully and serenely. We can experience serendipity in every moment.

We can be heroes.

Thank you, God for allowing me to be a hero. Amen.


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next: Happiness Is...

APA Reference
Staff, H. (2008, December 3). We Can Be Heroes, HealthyPlace. Retrieved on 2024, October 5 from https://www.healthyplace.com/relationships/serendipity/we-can-be-heroes

Last Updated: August 8, 2014

Happiness Is...

This past Sunday, my 14-year-old daughter needed my assistance on the computer. She was working on a school assignment and needed some clip art for a Happy Book that she was writing.

Some of you may recall the book, Happiness is a Warm Puppy by Charles Schultz. It consists of several "happiness is..." statements, as the title suggests.

My daughter's assignment was to create her own Happy Book and come up with several "happiness is..." statements. When she mentioned the project to me, several pedantic thoughts started going through my mind: we get so busy looking for happiness in a relationship, in a job, in our toys, and in our goals and dreams, that we forget to just be happy. We really don't have to go searching for happiness. We carry happiness inside us. We create happiness. We are the source of our own happiness. Sure, a certain type of happiness is derived from externals, but the externals should merely be reminders that we have access to all the happiness we want or need.

So together, my daughter and I searched the Internet for clip art that would prompt her thinking. It was a wonderful father-daughter exercise and it allowed me to see a creative side of my daughter I'd never seen before. She sat for a couple of hours going through image after image, chuckling and brainstorming over what she found.

Her favorite image was a grinning Zulu dancer. She wrote: "Happiness is looking at this cool dude in a grass skirt banging on his drum."

She showed me the image and it immediately brought a smile to my face. But so did the fact that my daughter had taught me an important lesson:

Happiness is what you decide brings you happiness.


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next: Responding to Feelings

APA Reference
Staff, H. (2008, December 3). Happiness Is..., HealthyPlace. Retrieved on 2024, October 5 from https://www.healthyplace.com/relationships/serendipity/happiness-is

Last Updated: August 8, 2014

Conquering Depression Enjoying Life

Article discusses why people get depressed and a new self-help method for recovering from depression. Written by Julian Simon, author of Good Mood:As of April, l975, I had been severely depressed almost every day for thirteen years--which is quite unusual. Then I braced myself for one last attempt to get rid of the depression before giving up the struggle against it. In the process, I discovered the psychological mechanism that is the proximate cause of sadness and depression. That discovery enabled me to take advantage of a couple of insights about myself. Within two weeks I had banished my depression.

Since April, l975, until now (September, 1990) I have been glad to be alive, and I have taken pleasure in my days. I have occasionally even been ecstatic, skipping and leaping from joy, especially in the early years when relief of the pain of depression was fresh. Though I must still fight off depression, I have not lost more than a minor skirmish since then, and I believe that--if my family and community stay safe from catastrophe--I have beaten depression for life. When I wrote the first draft of this article in 1978 (I then put it away to be sure that my cure was not just temporary) I wrote that "Even if I am wrong and eventually I suffer a permanent relapse, these three years of happiness and freedom from depression would leave me grateful for my good fortune." The good fortune continues, and I am more grateful than ever.

When I say that I was depressed for thirteen years, I mean that except for some of the hours when I was working or playing sports or making love, I was almost continuously conscious of being miserable, and I almost continuously reflected on my worthlessness. I wished for death, and I refused to kill myself solely because I believed that my children needed me, just as all children need a father. Endless hours every day I reviewed my faults and failures, which made me writhe in pain. To dramatize the matter: As I look back now, I'd rather have a tooth pulled, and have the operation bungled, or have the worst possible case of flu, in comparison to re-living any one of those days feeling as I did then.

By "depression," psychiatrists and psychologists mean a state of mind in which you are 1) sad or "blue", and 2) have a low regard for yourself. This article explains the mechanism that makes a person sad. After you understand it you can alter the mechanism in a variety of ways that can alleviate sadness and depression. The mechanism does not by itself produce or explain low self-regard. But if you manipulate the mechanism properly you will not be pre-occupied and ravaged by low self-regard. Though this mechanism has been noted by others, its explanation had not been developed systematically and scientifically. The key elements have now been confirmed in experimental studies, however. And leading psychiatrists and psychologists agree that this is a sound way to deal with depression.

This is the mechanism that causes the sadness in depression: when-ever you think about yourself in an evaluative way--which most of us do frequently throughout the day-- your thought takes the form of a comparison between the state you think you are in, and some other hypothetical "benchmark" state of affairs. The benchmark state may be the state you think you ought to be in, the state you formerly were in, the state you expected or hoped to be in, or the state you aspired to achieve. The comparison will make you feel sad if the state you think you are in is less positive than the state you compare yourself to. Consider this formula:

Mood=Perceived state of oneself Hypothetical benchmark state

If the numerator in the Mood Ratio is high relative to the denominator--if the comparison is positive--you feel pleasure. If the numerator in the Mood Ratio is low relative to the denominator--that is, if the comparison is negative--you feel pain.1 And if you also feel helpless to change the situation or your thoughts, you will then feel sad. A continuation of this state of sadness hardens into depression.

The comparison may be with respect to many possible personal characteristics-- occupational success, personal relationships, health, and morality, for a few examples. You may compare yourself on several different characteristics from time to time. As long as the bulk of your self-comparison thoughts are negative over a sustained period of time, and you continue to feel helpless to change your situation, you will be depressed.

The most convincing proof that sadness is caused by the unfavorable comparison of actual and counterfactual situations is your own introspections. Check and you will observe negative self-comparisons prominent in your thoughts when you are sad--whether the sadness is part of a general depression or not. And there is now a good-sized body of technical studies showing that what are commonly called "negative thoughts" accompany depression and are unusually common among people who have a propensity for depression.

Only this analysis makes sense of such exceptional situations as the person who is poor in the world's goods but nevertheless is happy, and the person who "has everything" but is miserable; not only their actual situations affect their feelings, but also the benchmark comparisons they set up for themselves.

The sense of loss--which often is associated with the onset of depression--also is a negative comparison, a comparison between the way things were and the way they are now. A person who never had a fortune does not experience the loss of a fortune in a stock market crash, and does not suffer grief there from.

Before we discuss how you can manipulate the Mood Ratio in order to remove depression, let us compare this view of depression with the conventional psychological views of depression.


Freud and his followers--who until the past few decades dominated psychological thinking about depression in the twentieth century, have viewed depression simply as a result of loss. "Melancholy is in some way related to an unconscious loss of a love object, in contra distinction to mourning, in which there is nothing unconscious about the loss.... In grief the world becomes poor and empty; in melancholia it is the ego itself that becomes poor and empty" (l9l7-l925, p. l55). Freud arrived at this idea because he observed great similarity between the depression of people grieving after a death, and other depressives. But the idea of loss by itself is not useful as the central concept in understanding depression. Unless one employs a tortured logic, the notion of loss does not fit the psychological states of many depressives. For example, being convinced that one is of low moral character can feed one's depression, but it is not a loss in any meaningful sense; the person probably does not think of him/herself as ever having had the high level of morality that is the benchmark for the negative self-comparison. A Freudian may find a way to define this comparison as a loss, but such reasoning only confuses the issue.

The psychoanalysts then joined the Freudian notion of loss to the observed fact that people whose parents die, desert them, or cut them off emotionally in childhood, have a higher likelihood of adult depression than do other people. This observation was then combined with a medical approach to depression as an ailment that should be treated by dealing with the root cause of the childhood loss. This view of depression and its cure are diagrammed in Figure l. In this scheme, both the sadness and the negative self- comparisons are seen as symptoms of the underlying causes.

Figure 1

The medical view of depression has at least two crucial drawbacks: (l) the therapy based upon it does not have a good record of success in curing depression; and (2) even where it is successful, such therapy is enormously costly in time and money.

A very different view of depression--whose roots may be found in the emphasis on self-esteem by William James, who now is finally being recognized as the greatest of all psychologists, and a better student of human nature than Freud--is in the spirit of what is commonly called "cognitive psychotherapy". Cognitive psychotherapy, which by now is perhaps the dominant position in contemporary psychology, views the person's present thinking as in the middle of the chain of causality running from the person's childhood and present events at the input end to the sadness at the output end, as seen in Figure 2. The "irrational thinking" which both Albert Ellis and Aaron Beck emphasize as the cause of depression is consistent with this point of view.

Figure 2

At the foundation of the cognitive point of view is the age-old commonsense idea that each of us has at least some power to decide what we will spend our moments thinking about, and which other persons, events and ideas we will attend to. This is in sharp contrast with the psychoanalytic view, which considers our thoughts to be mainly determined by our personal history and present external events. Of course the difference between these two points of view is a matter of emphasis, but the emphasis is all- important in deciding how to tackle a case of depression.

The cognitive view holds that we can use their minds to deal with our inner problems just as we deal with our outer problems. For example, we assume that an ordinary person can say to himself or herself, "Now I'm going to stop watching television and start doing my income-tax return," and then the person can carry out that decision. Similar, the cognitive view is that you can say to yourself "Every time a customer makes me feel that I haven't done a good job, which usually puts me into a blue funk, I will remind myself how many of my customers appreciate me". Another example: In the cognitive approach, an excellent 40-year-old tennis player learns the habit of remembering, after a bad day on the courts, that he can beat 99% of the 20-year-old players, and also remembering how many people are not even physically fit to play tennis at all at age 40.

Self-Comparisons Analysis, as I call this point of view, is consistent with the cognitive view of human psychology that one can banish depression by changing the depressive's present mode of thinking. But the Mood Ratio is more precise in its identification of the depression mechanism than simply referring to "irrational thinking" or "negative thoughts" or "poor cognition". This formulation offers several avenues for fighting depression--by altering the numerator, or the denominator, or the dimension of evaluation, or the frequency of any evaluations, rather than focusing only on the numerator (and perhaps on the denominator), as do cognitive therapists. Furthermore, Self-Comparisons Analysis opens up a wholly new way of combating depressions that resist other approaches--Values Therapy.

Why Do Some People Have A Tendency To Get Depressed?

Unflattering self-comparisons come into everyone's mind from time to time. And everyone occasionally feels helpless. But some people--chronic depressives--continually make negative self-comparisons. Their prevailing mood therefore is sadness, and a sense of worthlessness accompanies the sadness even if the negative self-comparison apparently has nothing to do with the person's own worth--say, the loss of a beloved mate. Other depressives suffer from intermittent bouts of negative self-comparisons, either cyclically or irregularly. Both types of depressives have a special propensity to make negative self-comparisons.

How and why do some people get into the habit of making negative self-comparisons whereas other people do not? Among the possible influences are early separation of a child from a parent, especially by the parent's death; cold, unloving, or untrustworthy parents; genetic-chemical biological inheritance; overly-ambitious professional or moral aspirations; a series of experiences of failure and rejection in childhood or adulthood; and major personal or professional shocks in adulthood. It is usually a combination of influences that make any given person a depressive.

The depression sufferer wants to know: How can I, alone or with a counselor, alter these elements or their effects so as to produce fewer negative self-comparisons and hence less sadness, and thereby pull me out of depression?

The basic causes of the depression certainly are not irrelevant. And for any particular person it may prove reasonable or necessary to go back to the basic causes as part of curing the depression--or it may not be necessary or reasonable to do so. For now, let us focus on the fact that no matter what the basic cause is, there must be negative self-comparisons and a sense of helplessness or there will be no depression. To say the same thing positively: Eliminate the negative self-comparisons and/or the sense of helplessness, and you eliminate the depression, no matter what does or does not happen with the basic causes.


This analogy may help: Your mind is like a system of minor and major streams that join up to form a river, which then passes through a narrows before it flows toward your city. Sometimes the river breaks loose and floods the city. The streams are like the basic causes of the depression. You may or may not be able to identify which stream or combination of streams constitutes the original cause. And even if you are successful in identifying the causal streams, you may or may not be to dam up or re-channel it or them. But if you turn your attention to the narrows, you know that if you dam or re-channel the river at that point you can prevent the depression from flooding you with sadness.

The self-evaluative process is like the narrows. If you choke off or re-direct your thoughts at that point, you can prevent the damaging flow of negative self-comparisons.

The key element for understanding and dealing with depression, then, is the sadness- producing negative comparisons between one's actual and benchmark hypothetical situation, together with the conditions that lead a person to make such comparisons frequently and acutely and make you feel helpless to chance the situation.

How may we manipulate the comparison-producing mechanism so that we prevent the flow of negative self-comparisons? There are several possibilities for any given person; one or another may be successful, or perhaps some combination will prove best. The possibilities include: changing the numerator; changing the denominator; changing the dimensions upon which you compare yourself; and making no comparisons at all. Let's consider them one by one.

Improving Your Numerator

Are you as bad as you think you are? If you have an incorrect unflattering picture of some aspects of yourself that you consider important, then your self-comparison ratio will be negative fallaciously. That is, if you systematically bias your estimate of yourself in a manner that makes you seem to yourself objectively worse than you really are, then you open yourself to needless negative self-comparisons and depression.

Keep in mind that we are now talking about assessments of yourself that can be checked objectively. An example: Samuel G. complained that, in his terms, he was a consistent "loser" at everything he did. His counselor knew that he played ping-pong, and asked him whether he usually won or lost at ping-pong. Sam said that he usually lost. The counselor asked him to keep a record of the games he played in the following week. The record showed that Sam won a bit more often than he lost, a fact which surprised him. With that evidence in hand, he was then receptive to the idea that he was also giving himself a short count in other areas of his life, and hence unnecessarily producing a negative self-comparison ratio.

Biased self-estimates are what Beck calls "distortions of reality based on erroneous premises and assumptions" and Ellis calls "irrational thinking". Such biased assessments are similar to faulty research into the facts of your life situation. Just as a student can be taught to do valid social-science research in university, and just as a child in school can improve her information-gathering and reasoning with guided practice, so depressives in the course of psychotherapy can be taught better information-gathering and processing. And if a person judges his situation in the light of a biased sample of experience--that is, an incorrect "statistical" analysis of life data and an unsound definition of the situation--he is likely to misinterpret reality.

In many cases, bringing this habit of making biased self-assessments to depressives' attention has helped them to correct their information-gathering and information-analyzing processes, and hence to remove depression. In one case I observed, Rachel J. was a woman very successful in her profession who was often depressed for long periods of time whenever her job hit an unsuccessful outcome; in her mind she ignored all her successes while ruminating on the recent failure. I was able to teach this woman to keep in mind a wider sample of her experiences in her profession after she had a failure. This tactic lightened the pain of her sadness, and greatly shortened the periods she was depressed after professional rejections.

People can and do distort the facts about any of the aspects of their lives that are important to them Sometimes people simply have wrong information about the world and about how well others perform because they collect data in a biased fashion. One of the virtues of the "sexual revolution" is that people now have a lot more information about what other people do, and hence nowadays people are less likely to consider themselves unusual with respect to such activities as masturbation or oral sex. This means that fewer people give themselves negative self-ratings as a "sinner" or "pervert".

Others, however, underestimate themselves systematically because they have a need to compare themselves unfavorably with others. For example, Geraldine M. insisted that she was incapable of doing many ordinary things done by ordinary people, that she was "incompetent". This caused much sadness, even though she is in fact one of the most successful women in her occupation. She frequently cited her inability to ride a bicycle as an example. In exasperation, her husband found a teacher who, in two lessons, taught Geraldine to ride unassisted around a large parking lot. She never went near a bicycle again, however, continuing to insist that she could not "really" ride a bicycle and is really an incompetent person.

People like Geraldine cannot be helped simply by teaching them to collect information more accurately, as can the other type of person mentioned above. Rather, the Geraldine types must think through why they feel the need to bias the facts negatively. Some of them are afraid to accept positive facts because they are afraid they will be punished by others for doing well. For others, a rotten numerator gives them an excuse to themselves, or to others, not to do some things they don't want to do.

If you can raise your numerator--if you can find yourself to be a better person than you now think you are, on the facts--then you will make your self-comparisons more positive. By so doing you will reduce sadness, increase your good feeling, and fight depression.

Sweetening Your Denominator

"Compared to what?" Voltaire asked, when told that life is hard. The denominator is the standard of comparison that you habitually measure yourself against. Whether your self-comparison is favorable or unfavorable depends as much upon the denominator you use as upon the supposed facts of your own life. The standard of comparison can be what you hope to be, what you formerly were, what you think you ought to be, or what you think others--to whom you compare yourself--are like.


"Normal" people alter their denominators rather flexibly in accordance with the implicit rule that the denominator should be chosen in such a manner as will make you feel good about yourself. That is, the psychologically-normal tennis player chooses opponents who provide an even match--tough enough to provide invigorating competition, but sufficiently easy so one can win enough to feel successful. The depressive personality, on the other hand, may pick a strong opponent who almost always wins. (A person with another sort of problem picks an opponent who is so weak that he or she provides no exciting competition.)

In the more important of our life situations, however, it is not as easy as in tennis to choose an "appropriate" denominator for the standard of comparison. A boy who is physically weak and un-athletic relative to his grammar-school classmates is stuck with that as a fact. So is the child who is slow at learning arithmetic. So is the big-boned thick-bodied girl. A death of a spouse or child or parent is another fact which one cannot deal with as simply as one can change tennis partners.

Though the denominator that stares at you in the mirror may be fact, this does not mean that misery is your inexorable fate. People change schools, start new families, or retrain themselves for occupations that fit them better than the old ones. They find ways to accept difficult facts as facts, and to alter their thinking so that the unpleasing facts cease causing distress. But some people do not manage to free themselves from denominators that hag-ride them into depression, and sometimes all the way to death by suicide or other depression-caused disease.

We must know, therefore, how and why some people appropriately adjust their denominators while others do not. Some people do not change their denominators because they are unaware--for lack of experience or imagination or flexibility--of relevant possibilities. For example, until he got some advice, three-time occupational loser Joe T. had never even considered an occupation for which his talent later enabled him to succeed. Others are stuck with pain-causing denominators because parents insisted that unless the child would reach certain particular goals--say, a Nobel prize, or becoming a millionaire--the child could consider her/himself a failure in the parent's eyes. Still others believe that attaining certain goals--curing others of illness, or making a life- saving discovery, or bringing up several happy children--is a basic value in itself, and should not be altered simply because it causes pain to the person who holds that goal. Still others feel that they ought to have a denominator so difficult to attain that it stretches them to the utmost, and/or keeps them miserable.

The worst possible denominator is the belief that you should be perfect in everything that you do. Associated with this denominator often is the belief that you have an obligation to remind yourself of every lapse by constant self-criticism, and that you ought to punish yourself for each such departure from perfection as a device to flay you into better performance.

If a denominator is killing or depressing you, I recommend that you proceed in these steps, which run from easier to harder:

(l) Ask yourself honestly whether you would like to change your denominator to one that will give you less pain, sadness, and depression.

(2) If your answer was "no" in Step l, go to Step 6. If you answer "yes", then consider whether you can change the objective conditions that give rise to the denominator that yields negative self-comparison.

(3) If changing jobs, colleagues, or what-have-you is not the answer for you, ask yourself whether your denominator--the benchmark standard to which you compare yourself-- is one that you feel you "must" retain. If you feel no such powerful "must", change the benchmark.

(4) If you feel that you are unable to change the benchmark standard of comparison by deciding to do so, and if the benchmark is general (such as a level of occupational achievement) rather than specific (such as producing as many insurance sales as the average man or the top man in your firm) then you might consider delving into your past to learn when and how you developed that denominator. Sometimes this historical adventure in psychotherapy leads to changing the denominator.

(5) If you do not wish to, or cannot, dig into your personal history to discover the roots of the troublesome denominator, or if after finding out the origins of the denominator through a search of your personal history you still prefer to hold onto the benchmark standard of comparison, then you may get tougher with yourself: You may demand and require of yourself that, by act of will and habit, you give up the old standards and instead compare yourself to standards that will make your comparisons positive rather than negative.

Shutting off the pain of depression would seem to be irresistibly attractive. But for many people this is not compelling, as we shall see later. Hence you must look for another reason for changing the denominator by brute force. The reason can be that there is something else which is very very important to you--say, the well-being of a beloved spouse or children--which is being injured by your negative self-comparisons. That is, the importance to you for that reason of making yourself happy for the sake of spouse and children can be sufficiently great so that you are willing to make the decision, and to do the work of implementing the decision, to change the denominator by force. (I myself might have taken this course of action, but I took a related but somewhat different course as I'll describe below.)

Can this actually be done? Of course it can be done, and it is done all the time. Think of the paraplegics confined to wheelchairs after accidents who take up wheelchair basketball, enjoy it vastly, and stoutly refuse to compare themselves to players who can run and jump when they play (or to themselves before the accident). Think of the Danish novelist who, if she wrote in a world language such as English, would be read by millions instead of by only a few thousands of her compatriots; she keeps herself cheerful thinking of the importance of bringing fine stories to a small number of people in their native language. Think about the postal clerk who, when lamenting his inadequate salary, forces himself to compare that salary to his father's laborer's wage, and to the wages of postal clerks in Asia and Africa.

(6) If your response in step (l) was "no"--as it is for a surprising number of persons--ask yourself whether you don't work to change denominators because (a) you want to feel pain, or (b) because you think that the denominator you now have is so important in itself that you feel you should not allow yourself to change it just for your own well- being. If you want to feel pain, perhaps it is because you think you ought to feel pain because you are so "bad". This may turn out to be a problem in improving your numerator, finding out that you are not "really" as "bad" as you think you are when you objectively assess your supposed sins and the sins of other people.

If you don't want to change denominators because you believe that the denominator reflects your most basic values, then continue to step 7.

(7) If none of the foregoing devices for giving you a more livable denominator seems promising for you, then perhaps you will most successfully battle your depression by changing dimensions of comparison, or by reducing the number of comparisons, or with the help of Values Therapy. These tactics will be discussed in succeeding sections.


New Dimensions and Better Ratios

If you can't make the old Mood Ratio livable, then consider getting a new one. This is the way all of us treat a troublesome washing machine or a broken violin, and it also is a sound way to proceed with troublesome self-comparison ratios.

Finding the basis for personal comparisons on which one comes up positive is, in fact, the way that most people construct an image of themselves which makes them look good, to themselves and to others.

The life strategy of the healthy-minded person is to find a dimension on which he or she performs relatively well, then argue to oneself and to others that it is the most important dimension on which to judge a person.

A 1954 song by Johnny Mercer and Harold Arlen went like this: "You've got to accentuate the positive...Eliminate the negative...Latch on to the affirmative...Don't mess with Mister In-between." That sums up how most people arrange their view of the world and themselves so that they have self-respect. This is often unpleasant to other people, because the person who accentuates her or his own strengths is thereby accentuating what in other people is less positive. And the person often proclaims intolerantly that that dimension is the most important one of all. But this may be the price of self-respect and non-depression to many people--much of the price being paid by others.

A more attractive illustration: appreciating your own courage is often an excellent way to shift dimensions. If you have been struggling without much success for years to convince the world that your fish-meal protein is an effective and cheap way of preventing protein-deficiency diseases in poor children (an actual case), you may be greatly saddened if you dwell on the comparison between what you have achieved and what you aspire to achieve. But if you focus instead upon your courage in making this brave fight, even in the face of the lack of success, then you will give yourself an honest and respectable positive comparison which will make you feel happy rather than sad, and which will lead you to esteem yourself well rather than poorly.

Another example: Bert F. is a poet who has struggled for years to win readers and respect for his poetry--with only occasional small success and never a really big success. Whether it is his ideas or his unconventionally simple style that keep him from succeeding, he does not know. He continues to believe that his poetry is fine and exciting work, but the overwhelming critical disinterest in his work finally wore him down and left him depressed. After months of deep sadness he decided that he could at least give himself high marks for courage and fortitude. And now when his mind turns to the failure of his poems, he consciously directs his mind to his courage--and this lifts his spirit. There are many physically-disabled persons who struggle to learn and work against tough odds, and who keep up their spirits with much the same device.

Counting one's blessings is the traditional label for the act of focusing on dimensions that will make us happy: remembering one's good health when one loses one's money; remembering one's wonderful loving children when the job is a failure; remembering one's good friends when a false friend betrays one, or when a friend dies; and so on.

This anecdote--a question put to former astronaut Edwin E. Aldrin, Jr.--shows how a person may shift to new dimensions of life to find happiness.

The aftermath of Apollo II made me realize that I had no idea what I was looking for in my life. It took hospitalization for psychiatric treatment and the acceptance of myself as an alcoholic to make me see that faith, hope and love for people are infinitely better goals than individual achievement. (Family Weekly, February 26, l978, p. 2)

Some people, however, are not so flexible in their choice of dimensions on which to compare themselves; they cannot choose at will the best "line of goods" for them to carry. For others this is a matter of basic values; they will not accord importance to characteristics simply because it is psychologically convenient to do so. In some cases, people seem to get stuck with dimensions that cause them sadness because of destructive implanted values in childhood, for example, that one should get maximum formal education, or that one should not think bad thoughts. In some other cases, people seem to purposely focus only on dimensions which make them look bad in their self-comparisons; all of us have met people who live exemplary lives in all apparent respects but who flay themselves with scourging whips because they think they don't do enough for the community or for their aged parents or relatives.

How can you, even if you are the type that doesn't typically change dimensions of evaluation to suit your own psychological convenience, do so anyway? One way is to demand of yourself that you do so in the name of a higher value. This is another example of Values Therapy, and this is what cured me of my l3-year-long depression. The higher value was the welfare of my children, which I believed was being threatened by my continued depression. In my hierarchy of values, the welfare of my children was all-important. Therefore, I decided that I simply would not allow myself to make the comparisons of my actual occupational achievements to the aspirations I have had for my work, or to the achievements of some others whose work has been better received than mine. I determined that whenever such comparisons came into my mind I would either turn my mind toward other comparisons such as the wonderful health of our family relative to the bad health that luck could have given us, or to the happy home life I mostly have, or to the useful role I play in the lives of some friends and colleagues, or the peacefulness of our lives--or else I would make no comparisons at all. More about this in a moment.

The Sound of a Numerator Clapping

No self-comparisons, no sadness. And no sadness means no depression. So why don't we just get rid of self-comparisons completely?

A practicing Zen Buddhist with an independent income and a grown family can get along without making many self-comparisons. But for those of us who must struggle to achieve our ends in the workaday world, some self-comparisons are necessary to keep us directed toward achieving these ends. Nevertheless we can, if we try, reduce the number of self-comparisons by doing other things instead.

Absorbing work is perhaps the most effective device. It is usually available, and it requires no special discipline. While you are thinking about the task at hand, your attention is effectively diverted from comparing yourself to some benchmark standard. After my first year of depression, it was my ability to dive down into work for two to four hours every morning that gave me some respite from my constant pain of sadness and awareness of worthlessness.

Many depressed people do not manage to work. This may be because they feel hopeless that the work will amount to anything. But others may not work because they are not aware of the enormous therapeutic possibilities of work.


Another way to shut off self-comparisons is to care about other people's welfare, and to involve yourself in helping them. This old-fashioned remedy against depression-- altruism--has been the salvation of many. In a book reporting more than three decades of the life histories of a hundred Harvard students starting before World War II, George Vaillant documents how turning to altruistic activities saved several of these men from adulthood hells. Perhaps this is a fair translation of what Jesus meant when he said that in order to save one's life one must lose it--that is, by giving it to others.

How may one become altruistic? All I can suggest is that you may decide to do so, either because you come to realize that it is one of your most important values to be altruistic, or because you are so anxious to cease being depressed that you are willing to give part of your time and strength and thought to others, or some combination of both.

Meditation is the traditional Eastern method of banishing negative self-comparisons. The essence of meditation is to shift to that special mode of concentrated thinking in which one does not evaluate or compare, but rather simply experiences the outer and inner sensory events as full of interest but without emotion.

Making comparisons is the most basic element in any evaluation or judgment. Comparing is a process of developing and using abstract concepts to deal with the sensations that your mind receives from inside and outside your body. The various forms of meditations, and of Eastern religious practices generally, are devices to orient you away from abstraction, judgment, comparison, and evaluation, and toward the primitive sensations themselves. Meditation also points you toward the judgment-free perceptions of the sensory world, and perhaps toward cosmic imaginations that often arise from the elementary experience in meditation.

Some Eastern religious practitioners seek the deepest and most continuous meditation in order to banish physical suffering, while others do so for purely religious purposes. But the same mechanism may be used as a very effective weapon against negative self- comparisons and depression while participating in everyday life. When, while walking the dog or driving to work or trying to sleep, a negative self-comparison comes into your mind--"What an immoral louse I am," or "I just can't do anything right"--then you can turn off the comparing mode and turn on the experiencing mode by this well-known device: Breathe in with your diaphragm so that your belly inflates deeply and slowly, and then deflate slowly; then continue to repeat the cycle. At the same time focus your attention on your breathing, or on a leaf, or on some other unemotional stimulus, perhaps saying to yourself, "Don't criticize," or "I don't need to compare." Soon you may find yourself smiling--just as I now am smiling as I am breathing in accord with the instructions I've just written. (It is difficult to believe how powerful and exciting such breathing is until you have taught yourself to do it. Someday I'll write a piece entitled "Confessions of a sensual breather"). There are many excellent books on meditation by Easterners and Westerners that go into much more depth and detail, and describe varied approaches; a good paperback on this topic is The Relaxation Response by Herbert Benson and Miriam Z. Klipper.

Getting Back Hope

Negative self-comparisons by themselves do not make you sad. Instead, you may get angry, or you may mobilize yourself to change your life situation. But a helpless, hopeless attitude along with negative self-comparisons leads to sadness and depression. This has even been shown in rat experiments. Rats that have experienced a series of electric shocks which they cannot avoid, later behave with less fight and more depression with respect to electric shocks that they can avoid, than do rats that did not earlier experience unavoidable shocks. The rats that experienced unavoidable shocks also show chemical changes like those associated with depression in humans.

It behooves us, then, to consider how to avoid feeling helpless. One obvious answer in some situations is to realize that you are not helpless and you can change your actual state of affairs so that the comparison will be less negative. Sometimes this requires gradual relearning through a graded series of tasks that show you that you can be successful, eventually leading to success in tasks that at the beginning seemed overwhelmingly difficult to you. This is the rationale of many behavioral-therapy programs that teach people to overcome their fears of elevators, heights, going out in public, and various social situations.

Indeed, the rats mentioned in the paragraph above, which learned to be helpless when given inescapable shocks, were later taught by experimenters to learn that they could escape the later shocks. They then showed diminished chemical changes associated with depression after they had "unlearned" their original experiences.

Something Else: Values Therapy

You're at the end of your rope, let's say. You believe that your numerator is accurate, and you see no appealing way to change your denominator or your dimensions of comparison. Putting aside all comparisons, or reducing them radically, does not attract you or does not seem feasible for you. You'd rather stay away from anti-depression drugs and shock treatment. Is there still any hope for you?

Values Therapy may be able to rescue you from your end-of-the-rope desperation. And it can also help people who are not at the end of their ropes, in preference to other approaches to depression. The central element of Values Therapy is discovering within the depressed person a latent conflicting value or belief that causes the person to modify or constrain or oppose the belief (or value) that leads to the negative self-comparisons. Russell describes his passage from a sad childhood to happy maturity in this fashion:

Now, on the contrary, I enjoy life; I might almost say that with every year that passes I enjoy it more. This is due partly to having discovered what were the things that I most desired, and having gradually acquired many of these things. Partly it is due to having successfully dismissed certain objects of desire--such as the acquisition of indubitable knowledge about something or other--as essentially unattainable. (Russell, l930, p. l5, italics added.)

The discovered value may be (as it was for me) the value that says directly that life should be happy rather than sad. Or it may be a value that leads indirectly to a reduction in sadness, such as the value (which also acted in me) that one's children should have a life-loving parent to imitate.


The discovered value may lead you to accept yourself for what you and your limitations are, and to go on to other aspects of your life. A person with an emotionally-scarred childhood, or a polio patient confined to a wheelchair, may finally accept such a fact as fact, cease railing at and struggling against fate, and decide not to let these handicaps dominate but rather to pay attention to what one can contribute to others with a joyful spirit, or how one can be a good parent by being happy.

Value Therapy need not always proceed systematically. But a systematic procedure may be helpful to some. At the least it makes clear what operations are important in Value Therapy. Such a systematic procedure may be described as follows:

Step l): Ask yourself what is important to you, what you most want in your life. Write down the answers. The list may be long, and it is likely to include very disparate sorts of items ranging from peace in the world and professional success, to a new car every other year and your oldest daughter being more polite to her grandmother.

Step 2): Now order these desires according to their importance to you. One simple way to do this is to put numbers on each want, running from, say, "l" (all-important) to "5" (not very important).

Step 3): Now ask yourself whether any really important things have been left off your list. Good health for yourself and your family? The present and future happiness of your children or spouse? The feeling that you are living an honest life? Remember to include matters that might seem important when looking back on your life at age seventy that might not come to mind now, such as spending plenty of time with your children, or having a reputation as a person who is helpful to others.

Step 4): Next, examine the list to see where there are conflicts, and/or if there are conflicts that are resolved in a manner that contradicts the indications of importance that you accord to the various elements. For example, you may put health for yourself in the top rank, and professional success in the second rank, but you may be working so hard for professional success that you are doing serious harm to your health, with depression as a result. Or--as was the case with me--the future and present happiness of my children is at the top of the list, and I believe that the chance that children will be happy in the future is much better if their parents are not depressed as the children are growing up. Close to the top but not at the top, is success in my work as measured by its impact upon the society. Yet in the past I had invested most of myself in my work. Furthermore, the results were not (at that time) a howling success in terms of their impact upon others, by my criteria. Therefore, thoughts about my work depressed me. This led to the discovery that if I am to live in accordance with my stated values and priorities, I must treat my work in some fashion that I do not let it depress me, for the sake of my children even if for no other reason.

In discussing other people's depressions with them, we usually discover some conflict between top-level values that demand that the person not be depressed, and lower- level values involved in causing the depression. The top-level value that life is a gift to be cherished and enjoyed is a frequent top-level value of this sort. More about that later.

Step 5): Take steps to resolve the conflicts between higher-order and lower-order values in such manner that higher-order values which require you not to be depressed are put in control. For example, if you recognize that too-hard work is injuring your health and depressing you, and that health is more important than the fruits of the extra work, you'll be more likely to face up to a decision to work less, and to avoid being depressed; a wise physician may put the matter to you in exactly this fashion. In my case, I had to recognize that I owe it to my children to somehow keep my work-life from depressing me. Many sorts of devices can help once you take on this task. With respect to work, it is often useful to make and enforce a less-demanding work schedule. Another device is to prepare and follow an agenda for future projects that promises a fair measure of success in completion and in reception. Still another device is to refuse to allow negative self- comparisons concerned with work to remain in your mind, either by pushing them out with brute force of will, or by training yourself to switch them off with behavior- modification, or with meditation techniques.

The result of the value-discovery process may be that a person becomes "twice born," by William James's term. This is radical therapy, like surgery that implants a second heart in a person to aid the leaky and failing original heart.

Values Therapy usually is not an easy and comfortable curve for depression. At the beginning, Values Therapy requires hard mental work and discipline, even with the aid of a counselor, in constructing an honest and inclusive graded list of what you want in life. After you have identified your most fundamental values, you remind yourself of those values whenever you start to make negative self-comparisons and get depressed. But it takes effort and dedication to keep reminding yourself of those values--just as it takes effort to remind another person of important matters when they are being forgotten. (The word "re-mind" is very precise.)

So staying undepressed with Values Therapy is not a piece of cake. But did you really expect otherwise? You'll have to judge for yourself whether the necessary effort is too high a price to pay for being free of depression.

More generally, all the techniques described here exact a price for overcoming depression. Many popular books promise that if you will just come to accept yourself, or just give yourself to God, or just love your neighbor with all your heart, you will immediately and miraculously and effortlessly go from sadness to bliss. Not likely. Such illusory promises can be destructive when they disappoint you. But if you are prepared to pay your dues, then you usually can overcome your depression.

Can You Fiddle Your Own Formula?

So, get your numerator straight, or change your denominator to one that produces positive comparisons, or choose other dimensions on which to compare yourself, or make no self-comparisons at all, or put your highest values in charge. Any or all of these devices may fit your situation and prove to be your own personal salvation.

But--can you climb out of depression by yourself, or must you have the help of a "doctor" to do it for you? I have been focusing on your capacity to help yourself. This is in contrast to the older psychoanalytical position that you are a patient who must have a therapist to "operate" on you. But all the newer scientifically-proven psychotherapeutic approaches and the psychological evidence agree in emphasizing the enormous possibilities for people to help themselves, to drag themselves up by their own bootstraps from depression, and thereby find new happiness.


You want evidence that people can successfully fight depression and find new happiness by one or another of these strategies. Stories of religious conversions are dramatic, as are newspaper anecdotes such as the Buzz Aldrin quote given earlier. Less- dramatic but better documented scientifically are the changes observed in depressed persons by practitioners of cognitive therapy such as Beck and Ellis, who work on clarifying people's numerators and sometimes altering their denominators. Also impressive proof that people can alter their moods by sheer decision and determination is the evidence of people's behavior on happy religious holidays, and especially the behavior of Orthodox Jews every Sabbath Saturday. No matter how miserable the person's life during the week, Jewish religious law requires that a person not be sad--not even to mourn the dead--on the Sabbath. And by and large, Orthodox Jews therefore manage to enjoy their lives on the Sabbath by demanding of themselves that they do so. In fact, though I am by no means an Orthodox Jew, three or four years before I cured my depression for seven days a week, I first found temporary surcease from my depression one day a week on the Sabbath.2

There is also rigorous scientific proof of the efficacy of cognitive therapy, proof that never existed before for any form of psychotherapy. The U. S. Public Health Service summarizes as follows: "Eighty percent of people with serious depression can be treated successfully. Medication or psychological therapies, or combinations of both usually relieve symptoms in weeks." Both kinds of treatment have been shown in controlled experimental research to benefit a large proportion of depression sufferers, within a few months or even weeks. Drugs, however, control the depression, whereas psychological therapy can cure it.

A counselor or therapist may help, of course, and may even be indispensable. But often the role played by the therapist is that of teacher, instructing you how to help yourself by new ways of thinking, which many of us are able to learn without hours of professional help.

Viewing the therapist as a "doctor" who has special helping powers that border on the miraculous may help you for a while, just as a sugar pill can bring improvement in physical ailments. If you are impressed by the promise of magic, a therapist may be able to re-educate you more effectively than a book or your own unaided powers can do alone. And of course a therapist may be a wise and experienced person who, like an experienced and wise teacher of any subject, can help you learn the ideas and the habits that fit your needs. But by no means every therapist is wise and helpful, even though highly trained. Some therapists point you in the wrong direction and mis-educate you because they cannot correctly assess what you need, or because they have been trained in only a single technique and use that technique willy-nilly even if it is appropriate for a given client, or because they are ignorant and stupid. (Yes, Virginia, people can earn Ph.D. degrees and yet be ignorant--even stupid--about everything except how to pass tests in school.)

My recommendation: First consider trying to banish your depression by yourself using the methods described here. If you can't manage satisfactorily, look for help. But be very discriminating about the therapist whom you choose, and don't be afraid to switch quickly if you judge that the therapist is not right for you. And try to understand what the therapist is doing in the framework of the New Happiness Formula.

Anti-depression Drugs, Electroshock and The Formula

Where do electroshock and anti-depression drugs fit into the picture? Drugs and electroshock can relieve painful sadness--at least after a while, and for a while--in many depression sufferers. Sometimes they also shake people out of vicious circles that keep them from making a curative attack on their problems. And sometimes these shock and drug treatments are enough to restore people to full normal life.

Electroshock and drugs sometime have physical and psychological side-effects, however. And for some people these techniques only postpone the day when they must finally reckon with the structure of their psyches, and come to grips with how they think, feel, and view the world and themselves. Furthermore, there can be great spiritual benefits in the self-understanding and self-satisfaction that one gains in mastering one's depression with one's own resources.

So--different strokes for different folks. You and your physician will have to decide about drugs and electroshock. As a general matter, however--try your own resources and Self-Comparisons Analysis first. If that works and makes drugs or electroshock unnecessary, so much the better.

Do You Really Want To Escape From Depression?

There is one indispensable element If you are to wrestle happiness out of depression: the desire not to be sad but rather to enjoy your life. At first that seems preposterous. Doesn't everyone want not to be sad? No. Many people get benefits from being sad, or are afraid of enjoying their lives, or don't want strongly enough to break out of sadness so that they are willing to make the effort to do so.

Being depressed allows you to feel sorry for yourself. Feeling sorry for yourself is the next most pleasant thing to loving yourself, and that in turn is almost as good as having others be attached to you and love you--which we all want and the lack of which is often a root cause of a person having a depressive nature. Another possible reason why a person does not fight depression is that any effort or exertion of the will implies a sort of pain, and the pain of the effort to crack the depression may seem greater than the pain of suffering from the depression. Still another reason is that the person may lack other strong desires which are inconsistent with being depressed--the desire that my children not be harmed by it, in my case. This brings us back to Values Therapy.

Some are so deeply mired in depression that they lack energy to break out of it. This latter state is "clinical depression," which may require drugs or electroshock or other radical therapy to get the person's motor started again so that the person has the will and the energy to reorganize her or his thinking to banish depression. But the reader of this piece--just because he or she has had the energy to find and read it--is not likely to be so lacking in resources with which to fight.


Once More With Good Feeling

Here once again in summary is the method: Check whether you can improve your numerator by accurately gathering the facts about yourself, and analyzing them appropriately. If that does not remove your depression, try sweetening your denominator by changing the standards against which you compare yourself. Next, consider evaluating yourself on dimensions different than those you now use. Additionally you may reduce the negative self-comparisons which produce sadness by reducing all comparisons and evaluations--with work, altruistic activity, or meditation.

For the person (a) whose numerator is not demonstrably at variance with the objective facts of his or her life, (b) who is not willing or able to change denominators for the sake of avoiding suffering, and (c) who will not change dimensions of comparison or stop making comparisons simply to avoid the pain of the depression, there may yet be another solution: Values Therapy. In Values Therapy you analyze your own personal desires in order to determine which values are most fundamental and important for you--your children's welfare, your spouse's welfare, your health, your contribution to others, material possessions, wealth, and so on. Then you go further and struggle to determine the hierarchy of these values--which are more important then which others. Next you consider whether achieving any of your most important values is inconsistent with being depressed--for example, the religious Jew's value for enjoying life on the Sabbath, or my value that my children have an undepressed father. If you can identify such important values, then if you are truthful with yourself you will bend every effort to force yourself to avoid negative self-comparisons even at the cost (at first) of energy and thought (later it becomes a habit), and you will give up the benefits of depression (feeling sorry for yourself, having an excuse not to do various chores, and so on).

It was this sort of values confrontation that broke my depression and allowed me to attain reasonably steady enjoyment of life, with occasional bliss and even the touch of ecstasy that is my happy lot now.

If Self-Comparisons Analysis and Values Therapy help you as much as I believe they can, this will improve my numerator, and make it even easier for me to keep winning my fight against depression. If out of my pain can come less pain and sadness for you, that, for me, is the bottom line.

FOOTNOTES

1Mathematical purists may notice that I sometimes say that this "ratio is negative" when it is really positive but less than one. When I say the "ratio is negative" I mean that the comparison of numerator to denominator is negative.
2Holidays such as Christmas also affect many depressives negatively, but that is a different sort of mechanism that need not be discussed here. The depression mechanism causes the sadness. If you under-stand and manipulate the mechanism properly, you can get rid of the sadness. Figure 4 pictures the depression mechanism. It shows the main elements that influence whether a person is sad or happy at a given moment, and whether the person does or does not descend into the prolonged gloom of depression. From left to right, these sets of elements are as follows:
(l) Experiences in childhood, both the general pattern of child-hood and particularly traumatic experiences, if any.
(2) The person's adult history, with the recent experiences having the greatest weight.
(3) The actual conditions of the individual's present life, including relationships with people, and objective factors such as health, job, finances, and so on.
(4) The person's habitual mental states, his views of the world and himself. This includes his goals, hopes, values, demands upon himself, and ideas about himself, including whether he is effective or ineffective and important or unimportant.
(5) Physical influences such as whether he is tired or rested, and anti-depression drugs if any.
(6) The machinery of thought which processes the material coming in from the other elements and produces an evaluation of how the person stands with respect to the hypothetical situation taken for compar-ison. The main lines of influence from one element-set to another are also shown in Figure 4. Figure 4 Benson, Herbert, with Miriam Z. Klipper, The Relaxation Response (New York: Avon Books, 1976).

next: Good Mood: The New Psychology of Overcoming Depression References
~ back to Good Mood homepage
~ depression library articles
~ all articles on depression

APA Reference
Staff, H. (2008, December 3). Conquering Depression Enjoying Life, HealthyPlace. Retrieved on 2024, October 5 from https://www.healthyplace.com/depression/articles/conquering-depression-enjoying-life

Last Updated: June 20, 2016

Release Your Brakes!

Release Your Brakes!

Believe that dreamers are believers
And that believers are receivers.
Know this truth, that to believe is all it takes.
Just take heart, get past the losers,
Never quit, you're among choosers.
Choose that dream; set that goal; release your brakes!

It takes a special kind of caring,
And a lot of active sharing.
A better you, a better me, that's what it makes.
For success is but a journey
And we all win in this tourney,
Get out of tow; give in; let go; release your brakes!

Reach for your dream, your heart has spoken.
Full speed ahead, there's no use pokin',
You're a winner, why not stretch for winner's stakes?
Time is not all that you're losin'
For the best is yet for choosin'.
Step on your fears; shift your gears; release your brakes!

next: Relationship "Slump Busters"

APA Reference
Staff, H. (2008, December 3). Release Your Brakes!, HealthyPlace. Retrieved on 2024, October 5 from https://www.healthyplace.com/relationships/celebrate-love/release-your-brakes

Last Updated: May 27, 2015

Grief Recovery

Discover the importance of grief recovery, grief work and dealing with unresolved grief caused by a death, divorce or any significant emotional loss.

Does time really heal all wounds?

It is important for a person to grieve and complete their relationship to the pain and unfinished business caused by a death, divorce or any other significant emotional loss.

When is it time to do my "grief work?"

This is the most difficult question facing grievers. Part of the problem stems from the biggest single inaccurate idea that we were all socialized to believe: that "time heals all wounds." Time does not heal. Actions can help discover and complete unfinished emotional business.

Discover the importance of grief recovery, grief work and dealing with unresolved grief caused by a death, divorce or any significant emotional loss.When can I begin to discover and complete all of the things that I wish had ended "different, better or more," and all of the broken "hopes, dreams, and expectations" about the future? The answer is immediately, according to John W. James, author of The Grief Recovery Handbook. "Waiting to do grief work is potentially dangerous," he says.

Most likely you've heard that grievers tend to create larger than life memory pictures in which they either "enshrine or bedevil" the person who died. According to James, this phenomenon increases with time, making it more difficult to discover the "truth" within the relationship.

What are some tipoffs that unresolved grief is the cause of my discomfort?

Unresolved grief tends to take people "out of the moment," that is to cause you to be off in conversations with people who are no longer physically there with you. [This is not limited to death. You are equally likely to be lost in a conversation with a former spouse, still living, who is not physically present]. Assuming that your physical health is okay, unresolved grief tends to drain you of energy. Unresolved grief tends to close our hearts down. Since we're incomplete with a prior loss, we almost automatically "protect" ourselves by not loving again. More accurately, we limit our loving exposure and thereby doom the new relationship to fail.

Commonly, grievers will hide their true feelings for fear of being judged. Where isolation is the problem, participation is a major component of the solution. Support groups, counseling, and workshops are all aimed at discovering and completing the unfinished emotional business that fuels the isolation.

next: My Experience With Depression
~ depression library articles
~ all articles on depression

APA Reference
Gluck, S. (2008, December 3). Grief Recovery, HealthyPlace. Retrieved on 2024, October 5 from https://www.healthyplace.com/depression/articles/grief-recovery

Last Updated: June 24, 2016